CCRF-CEM細胞株における細胞内活性化関連遺伝子発現の変化とAktの誘導がネララビンに対する獲得抵抗性に寄与している

• Material Type: 博士論文
• Title: CCRF-CEM細胞株における細胞内活性化関連遺伝子発現の変化とAktの誘導がネララビンに対する獲得抵抗性に寄与している
• Author/Editor: リンディアルティ, アルミトラ
• Author Heading: リンディアルティ, アルミトラ
• Publication, Distribution, etc.: Taylor & Francis
• Alternative Title: Changes in intracellular activation-related gene expression and induction of Akt contribute to acquired resistance towards nelarabine in CCRF-CEM cell line
• Degree grantor/type: 鹿児島大学
• Date Granted: 2022-05-30
• Dissertation Number: 甲総研第659号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: T-cell acute lymphoblastic leukemia; drug resistance; nelarabine; combination therapy; PI3K/Akt pathway
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Drug resistance is a major problem in treatment with nelarabine, and its resolution requires elucidation of the underlying mechanisms. We established two nelarabine-resistant subclones of the human T-cell lymphoblastic leukemia cell line CCRF-CEM. The resistant subclones showed changes in the expression of several genes related to nelarabine intracellular activation and inhibition of apoptosis. Activation of the Akt protein upon nelarabine treatment was observed in both subclones. The combination treatment with nelarabine and PI3K/Akt inhibitors was shown to inhibit cell growth. Cross-resistance was observed with ara-C and not with vincristine, daunorubicin, or etoposide treatment. Thus, changes in the expression of cellular activation-related genes, inhibition of apoptosis, and induction of Akt may be involved in the development of nelarabine resistance in the CCRF-CEM cell model. The use of different classes of chemotherapeutic agents and combination therapy with PI3K/Akt pathway inhibitors may be used to overcome resistance to nelarabine. Almitra Rindiarti, Yasuhiro Okamoto, Shunsuke Nakagawa, Junko Hirose, Yuichi Kodama, Takuro Nishikawa, Yoshifumi Kawano Changes in intracellular activation-related gene expression and induction of Akt contribute to acquired resistance toward nelarabine in CCRF-CEM cell line Leukemia & Lymphoma v.63(2) P.404-415 (2022) This is an Accepted Manuscript of an article published by Taylor & Francis in Leukemia & Lymphoma on 26 Jan 2022, available at: https://doi.org/10.1080/10428194.2021.1992617
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_Almitra_Rindiarti_isk_659 other

Comments_Almitra_Rindiarti_isk_659 other

Diss_アルミトラ_リンディアルティ_ISK659_2022 fulltext

Abstract_アルミトラ_リンディアルティ_4516800249_2022 abstract