日本人の健診データを用いた高血圧発症リスク予測スコアの開発

• Material Type: 博士論文
• Title: 日本人の健診データを用いた高血圧発症リスク予測スコアの開発
• Author/Editor: 川添, 真理子
• Author Heading: 川添, 真理子 カワソエ, マリコ
• Publication, Distribution, etc.: Springer Nature
• Alternative Title: Development of a risk prediction score for hypertension incidence using Japanese health checkup data
• Degree grantor/type: 鹿児島大学
• Date Granted: 2022-05-30
• Dissertation Number: 甲総研第662号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Diabetes; Hypertension; Obesity; Prediction score; Smoking
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Hypertension is a risk factor for cardiovascular disease. We developed a simple scoring method for predicting future hypertension using health checkup data. A total of 41,902 participants aged 30–69 years without baseline hypertension who underwent annual health checkups (mean age, 52.3 ± 10.2 years; male, 47.7%) were included. They were randomly assigned to derivation (n = 27,935) and validation cohorts (n = 13,967) at a ratio of 2:1. In the derivation cohort, we performed multivariable logistic regression analysis and assigned scores to each factor significantly associated with 5-year hypertension. We evaluated the predictive ability of the scores using area under the curve (AUC) analysis and then applied them to the validation cohort to assess their validity. The score including items requiring blood sampling ranged from 0 to 14 and included seven indicators (age, body mass index, blood pressure, current smoking, family history of hypertension, diabetes, and hyperuricemia). The score not including items requiring blood sampling ranged from 0 to 12 and included five indicators (the above indicators, except diabetes and hyperuricemia). The score not including items requiring blood sampling was better; blood sampling did not improve diagnostic ability. The AUC of the score not including items requiring blood sampling was 0.76, with a sensitivity and specificity of 0.82 and 0.60, respectively, for scores ≥6 points. The incidence of hypertension gradually and constantly increased (from 0.9 to 49.6%) as the score increased from 0 to ≥10. Analysis in the validation cohort yielded similar results. We developed a simple and useful clinical prediction model to predict the 5-year incidence of hypertension among a general Japanese population. The model had reasonably high predictive ability and reproducibility. Mariko Kawasoe, Shin Kawasoe, Takuro Kubozono, Satoko Ojima, Takeko Kawabata, Yoshiyuki Ikeda, Naoya Oketani, Hironori Miyahara, Koichi Tokushige, Masaaki Miyata & Mitsuru Ohishi Development of a risk prediction score for hypertension incidence using Japanese health checkup data Hypertension Research (2022) 45:730–740 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41440-021-00831-x
• Format (IMT): application/pdf
• Source: Diss_川添_真理子_4519810150_2022 （fulltext）; https://ir.kagoshima-u.ac.jp/record/16134/files/Diss_%E5%B7%9D%E6%B7%BB_%E7%9C%9F%E7%90%86%E5%AD%90_4519810150_2022.pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ