冠動脈バイパス術後における血小板中VEGF-Aと血清中microRNA-126の解析

• Material Type: 博士論文
• Title: 冠動脈バイパス術後における血小板中VEGF-Aと血清中microRNA-126の解析
• Author/Editor: 向原, 公介
• Author Heading: 向原, 公介 ムカイハラ, コウスケ
• Publication, Distribution, etc.: Springer Nature
• Alternative Title: Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting
• Degree grantor/type: 鹿児島大学
• Date Granted: 2023-03-10
• Dissertation Number: 甲総研第683号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: VEGF-A; Platelet; MicroRNA; MiR-126; CABG
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Platelet functions are thought to contribute to clinical outcomes after heart surgery. This study was conducted to assess the pivotal roles of vascular endothelial growth factor-A (VEGF-A) and microRNA-126 (miR-126) during coronary artery bypass grafting (CABG). Whole blood was collected for platelet isolation from 67 patients who underwent CABG surgery between July 2013 and March 2014. VEGF-A and miR-126 levels in serum, plasma, and platelets were measured at various time points and compared with clinical characteristics. The platelet count was decreased at 3 days after CABG. This dynamic change in platelet count was larger after conventional coronary artery bypass (CCAB) than off-pump coronary artery bypass (OPCAB). VEGF-A in the same number of platelets (IP-VEGF-A) was increased at 3 days after CABG, followed by an increase of VEGF-A in serum (S-VEGF-A) at 7 days after surgery. The miR-126-3p level in serum (S-miR-126-3p) increased rapidly after CABG and then decreased below preoperative levels. The IP-VEGF-A level on day 7 after CABG in patients with peripheral artery disease (PAD), who suffered from endothelial dysfunction, was higher compared with patients without PAD. Conversely, S-miR-126-3p on day 7 after surgery was lower in patients with PAD than in patients without PAD. Low levels of S-miR-126-3p due to endothelial dysfunction may lead to high IP-VEGF-A, which is closely related to complications after CABG. Kosuke Mukaihara, Munekazu Yamakuchi, Hideaki Kanda, Yoshiya Shigehisa, Kenichi Arata, Kazuhisa Matsumoto, Kazunori Takenouchi, Yoko Oyama, Toyoyasu Koriyama, Teruto Hashiguchi & Yutaka Imoto Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting Heart and Vessels 36, 1635–1645 (2021) This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00380-021-01855-6
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_MUKAIHARA_Kosuke_isk_683 other

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Diss_向原_公介_ISK683_2022 fulltext

Abstract_向原_公介_4514810255_2022 abstract