不十分な血圧コントロールは独立して動脈硬化度の進行と関連する

Material type: 博士論文

Author: 川畑, 孟子

Publisher: Springer Nature

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Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Hypertension is a risk factor for atherosclerosis. Achieving the therapeutic target value of blood pressure (BP) pre...

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Material Type: 博士論文
Title: 不十分な血圧コントロールは独立して動脈硬化度の進行と関連する
Author/Editor: 川畑, 孟子
Author Heading: 川畑, 孟子カワバタ, タケコ
Publication, Distribution, etc.: Springer Nature
Alternative Title: Insufficient blood pressure control is independently associated with increased arterial stiffness
Degree grantor/type: 鹿児島大学
Date Granted: 2023-03-23
Dissertation Number: 甲総研第693号
Degree Type: 博士(医学)
Doctor of Philosophy in Medical Science
Text Language Code: eng
Subject Heading: Antihypertensive agents
Blood pressure
Risk factors
Vascular stiffness
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Hypertension is a risk factor for atherosclerosis. Achieving the therapeutic target value of blood pressure (BP) prevents the onset of cardiovascular events; however, it is not clear how antihypertensive drug use and BP control status relate to arterial stiffness. The purpose of this study is to investigate the relationship between BP control status with or without antihypertensive drugs and arterial stiffness. Nine hundred eighty individuals (mean age: 68 ± 11 years) who participated in a community-based cohort study were enrolled. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI). Higher BP was defined as a systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg. Participants were divided into four groups: normal, non higher BP without antihypertensive drugs (n = 421); untreated, higher BP without antihypertensive drugs (n = 174); good control, non higher BP with antihypertensive drugs (n = 209); and poor control, higher BP with antihypertensive drugs (n = 176). In multivariable logistic analysis adjusted for age, sex, dyslipidemia and diabetes mellitus medication use, obesity, smoking, alcohol drinking, and heart rate at the CAVI measurement for a high CAVI—using a borderline cutoff value of 8.0—the other three groups were significantly associated with a high CAVI when compared with the normal group. By contrast, multivariable logistic analysis of a high CAVI using an abnormal cutoff value of 9.0 demonstrated that the poor control and untreated groups were significantly associated with a high CAVI, whereas the good control group was not. In conclusion, even with antihypertensive drugs, poor BP control is independently associated with a high CAVI. Takeko Kawabata, Takuro Kubozono, Satoko Ojima, Shin Kawasoe, Yuichi Akasaki, Anwar Ahmed Salim, Yoshiyuki Ikeda, Masaaki Miyata, Toshihiro Takenaka & Mitsuru Ohishi Insufficient blood pressure control is independently associated with increased arterial stiffness Hypertension Research 45, 1861–1868 (2022) https://doi.org/10.1038/s41440-022-01039-3
Format (IMT): application/pdf
Source: Diss_川畑_孟子_ISK693_2022 （fulltext）
https://ir.kagoshima-u.ac.jp/record/16537/files/Diss_%E5%B7%9D%E7%95%91_%E5%AD%9F%E5%AD%90_ISK693_2022.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ