シリンジ分注したω3系脂肪乳剤は気密性を保持し冷所保存すべきである: 貴重な未承認脂肪乳剤を有効かつ安全に供給するために

Material type: 博士論文

Author: 瀬戸口, 誠

Publisher: Wiley

Publication date: -

Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Background: Both fish-oil lipid injectable emulsion (FO-ILE) and mixed-oil lipid injectable emulsion (MO-ILE) are ke...

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Material Type: 博士論文
Title: シリンジ分注したω3系脂肪乳剤は気密性を保持し冷所保存すべきである: 貴重な未承認脂肪乳剤を有効かつ安全に供給するために
Author/Editor: 瀬戸口, 誠
Author Heading: 瀬戸口, 誠セトグチ, マコト
Publication, Distribution, etc.: Wiley
Alternative Title: Syringe-dispensed omega-3 lipid injectable emulsions should be stored under airtight refrigeration: a proposal for the efficient supply of unapproved precious lipid resources
Degree grantor/type: 鹿児島大学
Date Granted: 2023-03-23
Dissertation Number: 甲総研第694号
Degree Type: 博士(医学)
Doctor of Philosophy in Medical Science
Text Language Code: eng
Subject Heading: injectable lipid emulsions
intestinal failure
lipid peroxidation
malondialdehyde
parenteral nutrition
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Background: Both fish-oil lipid injectable emulsion (FO-ILE) and mixed-oil lipid injectable emulsion (MO-ILE) are key components of parenteral nutrition and require importation into Japan, and they are easily oxidized after opening. Given the small daily volumes of these lipids dispensed in infants and children with intestinal failure (IF), the purpose of the study was to identify the optimal storage method. Methods: Lipids were prepared in polypropylene syringes in the following manner: air-sealing and photoprotection, air-sealing only, photoprotection only, and uncovered. Samples were stored for 14 days at 4°C or 26°C. The degree of oxidative degradation was evaluated by measuring malondialdehyde (MDA) concentration and pH and comparing them to the values measured immediately after opening. Results: For FO-ILE, the increase in MDA concentration for 14 days was insignificant in air-sealed samples, regardless of photoprotection (+0.45 μM, P = 1.0) or no photoprotection (+0.52 μM, P = 1.0). This trend was more pronounced at 4°C than at 26°C (P < 0.01). The maximum pH decrease was 0.08 at 4°C. MO-ILE exhibited an insignificant increase in MDA concentration for 14 days with air-sealed samples, regardless of photoprotection (+0.36 μM, P = 0.11) or no photoprotection (+0.33 μM, P = 0.76). This trend was more pronounced at 4°C than at 26°C (P < 0.01). The maximum pH decrease was 0.12 at 4°C. For soybean-oil lipid injectable emulsion, the trend was similar with no considerable deterioration. Conclusion: Syringe-dispensed FO-ILE and MO-ILE stored under airtight refrigeration remained undeteriorated for 14 days. Our results are considered clinically valuable when supplying these expensive resources for infants with IF. This is the peer reviewed version of the following article: [ Makoto Setoguchi, Mitsuru Muto, Tomonori Ohata, Ryuichi Fukuoka, Hirohito Ikeda, Hatsumi Aki, Masaomi Haraguchi, Shota Hanjo, Junko Arima, Satoshi Ibara Syringe-dispensed omega-3 lipid injectable emulsions should be stored under airtight refrigeration: A proposal for the efficient supply of unapproved precious lipid resources Journal of Parenteral and Enteral Nutrition. 2022;46:1923–1931. ], which has been published in final form at [ https://doi.org/10.1002/jpen.2443 ]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Format (IMT): application/pdf
Source: https://ir.kagoshima-u.ac.jp/record/16538/files/Diss_瀬戸口_誠_ISK694_2022.pdf （fulltext）
https://ir.kagoshima-u.ac.jp/record/16538/files/Diss_%E7%80%AC%E6%88%B8%E5%8F%A3_%E8%AA%A0_ISK694_2022.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ