胆嚢微生物叢と膵胆管・胆嚢がんの予後との関連

Material type: 博士論文

Author: 霧島, 茉莉

Publisher: BioMed Central

Publication date: -

Material Format: Digital

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Name of awarding university/degree: 鹿児島大学,博士(医学),Doctor of Philosophy in Medical Science

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Note (General)：: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Background: The microbial population of the intestinal tract and its relationship to specific diseases has been exte...

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Material Type: 博士論文
Title: 胆嚢微生物叢と膵胆管・胆嚢がんの予後との関連
Author/Editor: 霧島, 茉莉
Author Heading: 霧島, 茉莉キリシマ, マリ
Publication, Distribution, etc.: BioMed Central
Alternative Title: Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis
Degree grantor/type: 鹿児島大学
Date Granted: 2023-04-18
Dissertation Number: 甲総研第699号
Degree Type: 博士(医学)
Doctor of Philosophy in Medical Science
Text Language Code: eng
Subject Heading: Pancreaticobiliary tract
Gallbladder
Cancer
Bile
Microbiota
Alpha diversity
Beta diversity
Overall survival
Prognosis
Biomarker
Target Audience: 一般
Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Background: The microbial population of the intestinal tract and its relationship to specific diseases has been extensively studied during the past decade. However, reports characterizing the bile microbiota are rare. This study aims to investigate the microbiota composition in patients with pancreaticobiliary cancers and benign diseases by 16S rRNA gene amplicon sequencing and to evaluate its potential value as a biomarker for the cancer of the bile duct, pancreas, and gallbladder. Results: We enrolled patients who were diagnosed with cancer, cystic lesions, and inflammation of the pancreaticobiliary tract. The study cohort comprised 244 patients. We extracted microbiome-derived DNA from the bile juice in surgically resected gallbladders. The microbiome composition was not significantly different according to lesion position and cancer type in terms of alpha and beta diversity. We found a significant difference in the relative abundance of Campylobacter, Citrobacter, Leptotrichia, Enterobacter, Hungatella, Mycolicibacterium, Phyllobacterium and Sphingomonas between patients without and with lymph node metastasis. Conclusions: There was a significant association between the relative abundance of certain microbes and overall survival prognosis. These microbes showed association with good prognosis in cholangiocarcinoma, but with poor prognosis in pancreatic adenocarcinoma, and vice versa. Our findings suggest that pancreaticobiliary tract cancer patients have an altered microbiome composition, which might be a biomarker for distinguishing malignancy. Mari Kirishima, Seiya Yokoyama, Kei Matsuo, Taiji Hamada, Michiko Shimokawa, Toshiaki Akahane, Tomoyuki Sugimoto, Hirohito Tsurumaru, Matsujiro Ishibashi, Yuko Mataki, Takao Ootsuka, Mitsuharu Nomoto, Chihiro Hayashi, Akihiko Horiguchi, Michiyo Higashi & Akihide Tanimoto Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis BMC Microbiology (2022) 22:147 https://doi.org/10.1186/s12866-022-02557-3
Format (IMT): application/pdf
Source: Diss_霧島_茉莉_ISK699_2023 （fulltext）
https://ir.kagoshima-u.ac.jp/record/16655/files/Diss_%E9%9C%A7%E5%B3%B6_%E8%8C%89%E8%8E%89_ISK699_2023.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ