胆嚢微生物叢と膵胆管・胆嚢がんの予後との関連

• Material Type: 博士論文
• Title: 胆嚢微生物叢と膵胆管・胆嚢がんの予後との関連
• Author/Editor: 霧島, 茉莉
• Author Heading: 霧島, 茉莉 キリシマ, マリ
• Publication, Distribution, etc.: BioMed Central
• Alternative Title: Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis
• Degree grantor/type: 鹿児島大学
• Date Granted: 2023-04-18
• Dissertation Number: 甲総研第699号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Pancreaticobiliary tract; Gallbladder; Cancer; Bile; Microbiota; Alpha diversity; Beta diversity; Overall survival; Prognosis; Biomarker
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Background: The microbial population of the intestinal tract and its relationship to specific diseases has been extensively studied during the past decade. However, reports characterizing the bile microbiota are rare. This study aims to investigate the microbiota composition in patients with pancreaticobiliary cancers and benign diseases by 16S rRNA gene amplicon sequencing and to evaluate its potential value as a biomarker for the cancer of the bile duct, pancreas, and gallbladder. Results: We enrolled patients who were diagnosed with cancer, cystic lesions, and inflammation of the pancreaticobiliary tract. The study cohort comprised 244 patients. We extracted microbiome-derived DNA from the bile juice in surgically resected gallbladders. The microbiome composition was not significantly different according to lesion position and cancer type in terms of alpha and beta diversity. We found a significant difference in the relative abundance of Campylobacter, Citrobacter, Leptotrichia, Enterobacter, Hungatella, Mycolicibacterium, Phyllobacterium and Sphingomonas between patients without and with lymph node metastasis. Conclusions: There was a significant association between the relative abundance of certain microbes and overall survival prognosis. These microbes showed association with good prognosis in cholangiocarcinoma, but with poor prognosis in pancreatic adenocarcinoma, and vice versa. Our findings suggest that pancreaticobiliary tract cancer patients have an altered microbiome composition, which might be a biomarker for distinguishing malignancy. Mari Kirishima, Seiya Yokoyama, Kei Matsuo, Taiji Hamada, Michiko Shimokawa, Toshiaki Akahane, Tomoyuki Sugimoto, Hirohito Tsurumaru, Matsujiro Ishibashi, Yuko Mataki, Takao Ootsuka, Mitsuharu Nomoto, Chihiro Hayashi, Akihiko Horiguchi, Michiyo Higashi & Akihide Tanimoto Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis BMC Microbiology (2022) 22:147 https://doi.org/10.1186/s12866-022-02557-3
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 鹿児島大学 : 鹿児島大学リポジトリ

Table of Contents

Result_KIRISHIMA_Mari_isk_699 other

Comments_KIRISHIMA_Mari_isk_699 other

Diss_霧島_茉莉_ISK699_2023 fulltext

Abstract_霧島_茉莉_4517810141_2023 abstract