Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats

Material type: 記事

Author: 松崎, 広和ほか

Publisher: BioMed Central

Publication date: 2013-12

Material Format: Digital

Journal name: BMC Complementary and Alternative Medicine 13

Publication Page: p.370-1-370-8

View All

Notes on use

Note (General)：: type:textBackground: Ganoderma lucidum is a popular medicinal mushroom used for promoting health and longevity in Asian countries. Previously, we repo...

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

JURA　(Josai University Repository of Academia)
Digital
You can check the holdings of institutions and databases with which 学術機関リポジトリデータベース（IRDB）（機関リポジトリ） is linked at the site of 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）.
JURA　(Josai University Repository of Academia)

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 記事
Title: Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats
Author/Editor: 松崎, 広和
清水, 裕太
岩田, 直洋
神内, 伸也
鈴木, 史子
飯塚, 博
日比野, 康英
岡﨑, 真理
Author Heading: 松崎, 広和
清水, 裕太
岩田, 直洋
神内, 伸也
鈴木, 史子
飯塚, 博
日比野, 康英
岡﨑, 真理
Publication, Distribution, etc.: BioMed Central
Publication Date: 2013-12
Publication Date (W3CDTF): 2013-12
Periodical title: BMC Complementary and Alternative Medicine
No. or year of volume/issue: 13
Volume: 13
Pages: 370-1-370-8
ISSN (Periodical Title): ISSN : 1472-6882
Text Language Code: eng
Subject Heading: Anxiety
Depression
Ganoderma lucidum mycelia
Locomotion
Memory
5-HT2A receptors
Target Audience: 一般
Note (General): type:text
Background: Ganoderma lucidum is a popular medicinal mushroom used for promoting health and longevity in Asian countries. Previously, we reported that a water-soluble extract from a culture medium of Ganoderma lucidum mycelia (MAK) exerts antioxidative and cerebroprotective effects against ischemia?reperfusion injury in vivo. Here, we evaluated the antidepressant and anxiolytic activities of MAK in rats. Methods: MAK (0.3 or 1 g/kg, p.o.) was administered in the experimental animals 60 min before the forced swimming, open-field, elevated plus-maze, contextual fear-conditioning, and head twitch tests. Additionally, the mechanisms involved in the antidepressant-like action of MAK were investigated by the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP)- or 5-HT2A agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)-induced head twitch responses. Results: Treatment with MAK (1 g/kg) exhibited antidepressant-like effects in the forced swimming test, attenuated freezing behavior in the contextual fear-conditioning test, and decreased the number of head twitches induced by DOI, but not with 5-HTP. No significant response was observed in locomotion or anxiety-like behavior, when the animals were evaluated in the open-field or elevated plus-maze test, respectively. Conclusions: These data suggest that MAK has antidepressant-like potential, which is most likely due to the antagonism of 5-HT2A receptors, and possesses anxiolytic-like effects toward memory-dependent and/or stress-induced anxiety in rats.
8 p. Open Access
identifier:JOS-1472-6882-13-370
Format (IMT): application/pdf
Source: http://libir.josai.ac.jp/il/user_contents/02/G0000284repository/pdf/JOS-1472-6882-13-370.pdf
http://libir.josai.ac.jp/il/user_contents/02/G0000284repository/pdf/JOS-1472-6882-13-370.pdf
Access Restrictions: 限定公開
Related Material (DOI): 10.1186/1472-6882-13-370
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 城西大学 : JURA　城西大学機関リポジトリ