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- Material Type
- 規格・テクニカルリポート類
- Author/Editor
- 堀口 洋徳中村 剛実本橋 純樫村 隆則市村 茂樹笹島 文雄
- Publication Date
- 2012-03
- Publication Date (W3CDTF)
- 2012
- Alternative Title
- Characteristics measurement of JRR-4 neutron beam facility; Accuracy estimation of BNCT dose calculation after change of reflector
- Periodical title
- JAEA-Technology 2012-003
- Target Audience
- 一般
- Note (General)
- 出版タイプ： NA研究炉JRR-4では、悪性脳腫瘍や頭頸部癌等に対するホウ素中性子捕捉療法(BNCT)の臨床研究が実施されている。BNCTは、熱中性子と患者に投与されたホウ素($^{10}$B)との核反応を利用した放射線治療法である。JRR-4では、反射体要素の不具合に伴い、全種類の反射体要素について設計仕様の変更が行われた。新たな反射体要素の製作においては、計算解析により中性子ビーム設備への影響を考慮した設計を行っている。反射体要素の据え付け終了後、中性子ビーム設備の性能についてフリービーム実験及び水ファントム実験による確認を実施した。得られた実験結果と本解析手法による結果を比較することにより、BNCTの治療計画に必要となる計算誤差を評価することができた。Clinical trials of boron neutron capture therapy (BNCT) for malignant brain tumors and head and neck cancers have been performed at the research reactor JRR-4. BNCT is a kind of radiation therapy using a nuclear reaction with thermal neutrons and boron ($^{10}$B) elements administered to a patient. The design specifications of all types of reflector elements were changed due to a trouble of a reflector element in JRR-4. In the production of the new reflector elements, they were designed with the influence for the neutron beam facility by the analytical calculation. After the installation of the new reflector elements, the performance of the neutron beam facility was verified by measurement such as a free air experiment and a water phantom experiment. The calculation error used in the treatment planning for BNCT can be estimated by comparing the results of our calculation with the corresponding experimental data.
- Source
- /JAEA-Technology-2012-003.pdf （fulltext）