筋活動量及び血流量に関係した神経・筋の変性と運動の影響

Material type: 文書・図像類

Author: 石原, 昭彦ほか

Publisher: 宇宙航空研究開発機構

Publication date: 2006-03-31

Material Format: Digital

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Note (General)：: 生後10週齢の雄ラットに水平状態で2週間にわたり後肢懸垂を施した。その後、2週間にわたり実験動物用の加負荷式運動装置で自発的な走運動を施した。後肢懸垂後、ヒラメ筋でtype1線維の割合の減少、すべてのタイプの筋線維で萎縮と酸化系酵素活性の減少が認められた。後肢懸垂後に普通飼育で回復させた場合、筋線維...

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Material Type: 文書・図像類
Title: 筋活動量及び血流量に関係した神経・筋の変性と運動の影響
Author/Editor: 石原, 昭彦
Ishihara, Akihiko
Author Heading: 石原, 昭彦
Ishihara, Akihiko
Publication, Distribution, etc.: 宇宙航空研究開発機構
Publication Date: 2006-03-31
Publication Date (W3CDTF): 2006-03-31
Alternative Title: Effects of exercise on activity-and blood flow-related neuromuscular degeneration
Periodical title: 宇宙航空研究開発機構特別資料: 平成17年度ISS科学プロジェクト室神経生理研究プロジェクト研究開発報告 = JAXA Special Publication: FY2005 Research and Development Report on Neurophysiology Research Project at ISS Science Project Group
No. or year of volume/issue: JAXA-SP-05-040
Volume: JAXA-SP-05-040
Pages: 1-4
ISSN (Periodical Title): ISSN : 1349-113X
Text Language Code: jpn
Subject Heading: 後肢懸垂
萎縮
ラット
リハビリテーション
運動
骨格筋
微小重力
航空宇宙環境
血流
hindlimb suspension
atrophy
rat
rehabilitation
physical exercise
skeletal muscle
microgravity
aerospace environment
blood flow
Target Audience: 一般
Note (General): 生後10週齢の雄ラットに水平状態で2週間にわたり後肢懸垂を施した。その後、2週間にわたり実験動物用の加負荷式運動装置で自発的な走運動を施した。後肢懸垂後、ヒラメ筋でtype1線維の割合の減少、すべてのタイプの筋線維で萎縮と酸化系酵素活性の減少が認められた。後肢懸垂後に普通飼育で回復させた場合、筋線維の萎縮や変性は改善されなかった。一方、回復期に走運動を負荷した場合、type1線維の割合の減少や筋線維の萎縮と酸化系酵素活性の減少は改善された。後肢懸垂後、ヒラメ筋を神経支配する運動ニューロンの総数、細胞体サイズ、酸化系酵素活性に変化はみられなかった。一方、回復期に走運動を負荷した場合、運動ニューロンの酸化系酵素活性に増大が認められた。これらの結果より、加負荷を伴う走運動は、神経・筋の萎縮や変性を効果的に改善することが明らかになった。
Effects of running exercise with increasing loads on hindlimb unloading-induced neuromuscular degeneration in male rats were investigated. Ten-week-old male rats were hindlimb suspended at horizontal position for two weeks and thereafter were rehabilitated by voluntary running exercise with increasing loads for two weeks. A decreased percentage of type 1 fibers and atrophy and decreased oxidative enzyme activity of all types of fibers in the soleus muscle were observed after hindlimb unloading. In contrast, an improvement in the decreased percentage of type 1 fibers, decreased fiber cross-sectional area, and decreased fiber oxidative enzyme activity was observed after recovery with running exercise, but not without running exercise. There were no changes in the number, cell body size, or oxidative enzyme activity of spinal motoneurons innervating the soleus muscle after hindlimb unloading, while an increased oxidative enzyme activity of motoneurons was observed after recovery with running exercise, but not without running exercise. It is concluded that running exercise with increasing loads is beneficial for the recovery of neuromuscular degeneration, which was induced by hindlimb unloading.
資料番号: AA0049801001
レポート番号: JAXA-SP-05-040
Access Restrictions: 限定公開
Periodical Title (NCID): AA11984031
https://ci.nii.ac.jp/ncid/AA11984031
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 宇宙航空研究開発機構 : 宇宙航空研究開発機構リポジトリ