伸張性トレーニングに伴う筋損傷・筋肥大と遺伝的要因との関連性

Material type: 文書・図像類

Author: 越智, 英輔

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Publication date: 2018-06-20

Material Format: Digital

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Note (General)：: type:Working Paper研究成果の概要 (和文) : 本研究では、これまでの研究に遺伝子多型という新たな視点を加え、ヒト肘関節屈筋群における伸張性収縮運動を実施した際の筋損傷と遺伝的要因との関連性を検討することを目的とした。被験者はトレーニング習慣のない健常男性とし、肘関節屈筋群に負荷し...

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HOSEI UNIVERSITY REPOSITORY
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Material Type: 文書・図像類
Title: 伸張性トレーニングに伴う筋損傷・筋肥大と遺伝的要因との関連性
Author/Editor: 越智, 英輔
Author Heading: 越智, 英輔
Publication Date: 2018-06-20
Publication Date (W3CDTF): 2018-06-20
Alternative Title: The effects of genetic factors on skeletal muscle and joint functions before and after eccentric contractions
Pages: 1-5
Text Language Code: jpn
Subject Heading: 筋損傷
エキセントリック
関節可動域
ACTN3
αアクチニン3
柔軟性
筋力
Target Audience: 一般
Note (General): type:Working Paper
研究成果の概要 (和文) : 本研究では、これまでの研究に遺伝子多型という新たな視点を加え、ヒト肘関節屈筋群における伸張性収縮運動を実施した際の筋損傷と遺伝的要因との関連性を検討することを目的とした。被験者はトレーニング習慣のない健常男性とし、肘関節屈筋群に負荷した。その結果、伸張性運動前のACTN3R577X遺伝的多型は等尺性筋力発揮及び関節柔軟性と関連することを見いだすことができた。
研究成果の概要 (英文) : The purpose of present study was to examine the association between genotype and functional characteristics of elbow flexors before and after eccentric contractions (ECCs). Untrained men were recruited. Measurements of MVC torque, ROM, and muscle soreness were taken before, immediately after, 1, 2, 3, and 5 days after ECCs. Genotyping results were analyzed for identifying ACTN3 R577X polymorphism (rs1815739) using TaqMan approach. MVC at baseline was greater in RR homozygotes than in X-allele carriers (combined XX and RX; p < 0.05). ROM in RR homozygotes at baseline was lower than that of X-allele carriers. Although a significant decrease in ROM was observed in X-allele carriers until 3 days after ECCs, a significant ROM reduction in RR homozygotes was observed only immediately after ECCs. Our data indicated that ACTN3 RR genotype has higher MVC and lower flexibility than X-allele carriers at baseline, but effect of ACTN3 R577X genotype on these two parameters is limited after ECCs.
Source: https://hosei.ecats-library.jp//da/repository/00022299/18_kaken_15K01558seika.pdf
https://hosei.ecats-library.jp//da/repository/00022299/18_kaken_15K01558seika.pdf
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 法政大学 : 法政大学学術機関リポジトリ