Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study

• Material Type: 博士論文
• Title: Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study
• Author/Editor: Hirano, Masatoshi
• Author Heading: Hirano, Masatoshi
• Alternative Title: 低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより
• Degree grantor/type: 広島大学(Hiroshima University)
• Date Granted: 2014-01-23
• Dissertation Number: 甲第6278号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: High-density lipoprotein cholesterol; Type 2 diabetes; Westernized lifestyle
• NDC: 490
• Target Audience: 一般
• Note (General): type:text; Aims/Introduction: A low level of high-density lipoprotein cholesterol (HDLC) is a common feature of metabolic syndrome. We have reported that Japanese-Americans who share a virtually identical genetic makeup with native Japanese, but who have lived Westernized lifestyles for decades, have lower HDLC levels and a high prevalence of type 2 diabetes compared with native Japanese. However, the impact of low HDLC level on type 2 diabetes is unclear. The aims of the present study were to evaluate whether serum HDLC level was associated with development of type 2 diabetes and if the effect might be modified by lifestyle. Materials and Methods: We examined 1,133 non-diabetic Japanese-Americans and 1,072 non-diabetic Japanese, who underwent the 75-g oral glucose tolerance test (OGTT) and were followed for an average of 8.8 and 7.0 years, respectively. We analyzed whether serum HDLC level is a risk factor for development of type 2 diabetes based on the Cox proportional hazards model. Results: After adjustment for age and sex, hazard ratios for development of type 2 diabetes per unit of serum HDLC level (mmol/L) were 0.292 (95% confidence interval [CI] 0.186-0.458, P < 0.0001) among Japanese-Americans and 0.551 (95% CI 0.375-0.88, P = 0.0023) among native Japanese. Comparable hazard ratios after further adjustment for category of OGTT and body mass index were 0.981 (95% CI 0.970-0.993, P = 0.0018) and 0.991 (95% CI 0.980-1.002, P = 0.112), respectively. Conclusions: HDLC level was associated with development of type 2 diabetes in both Japanese-Americans and native Japanese. However, these results suggest that the impact of high-density lipoprotein on glucose metabolism might be affected by lifestyle.
• Format (IMT): application/pdf
• Source: fulltext; http://ir.lib.hiroshima-u.ac.jp/files/public/3/36282/20141121012533101826/k6278_3.pdf; http://ir.lib.hiroshima-u.ac.jp/files/public/3/36282/20181121144147879224/k6278_1.pdf; http://ir.lib.hiroshima-u.ac.jp/files/public/3/36282/20181121144148360115/k6278_2.pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright(c) by Author
• References (URI): URI; http://dx.doi.org/10.1111/jdi.12170
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 広島大学 : 広島大学学術情報リポジトリ