KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome.

• Material Type: 博士論文
• Title: KL-6, a Human MUC1 Mucin, as a prognostic marker for diffuse alveolar hemorrhage syndrome.
• Author/Editor: Kida, Yoshiko
• Author Heading: Kida, Yoshiko
• Alternative Title: びまん性肺胞出血症候群における予後因子としてKL-6の有用性についての検討
• Degree grantor/type: 広島大学(Hiroshima University)
• Date Granted: 2014-03-23
• Dissertation Number: 甲第6374号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: Prognosis; Survival; Outcome; Biomarker; Interstitial lung disease; Diffuse alveolar damage
• NDC: 490
• Target Audience: 一般
• Note (General): type:text; Background: Diffuse alveolar hemorrhage syndrome is a life threatening condition with diverse etiologies. Sensitive prognostic markers for diffuse alveolar hemorrhage have not been well investigated. Serum KL-6 is a biomarker for various interstitial lung disease associated with disease activity and prognosis. The purpose of the present study was to evaluate the clinical utility of serum KL-6 level as a prognostic marker for diffuse alveolar hemorrhage. Methods: We retrospectively collected 41 consecutive patients clinically diagnosed as having diffuse alveolar hemorrhage who were admitted to the Intensive Care Unit of Hiroshima University Hospital between 2004 and 2011. Correlation between prognosis and age, sex, laboratory findings including serum KL-6, radiological findings, ventilatory modes or therapeutic regimens were evaluated. Results: Baseline and peak serum KL-6 levels were significantly higher in non-survivors compared with survivors. An increase in KL-6 levels during the initial week was associated with a subsequent deterioration of the oxygenation index. Higher baseline KL-6 levels and higher peak KL-6 levels were strongly correlated with death. With a cut-off level of 700 U/mL for peak KL-6, the sensitivity, specificity and accuracy for non-survival were 75%, 85% and 78%, respectively. In the multivariate analysis, only the peak KL-6 level ?700 U/ml was an independent poor prognostic factor for diffuse alveolar hemorrhage. Conclusions: Peak serum KL-6 level ?700 U/ml may become a clinically useful marker of poor prognosis for diffuse alveolar hemorrhage.
• Format (IMT): application/pdf
• Source: comment：fulltext; http://ir.lib.hiroshima-u.ac.jp/files/public/3/36299/20141121014654290111/k6374_3.pdf; http://ir.lib.hiroshima-u.ac.jp/files/public/3/36299/20181121132138108032/k6374_1.pdf; http://ir.lib.hiroshima-u.ac.jp/files/public/3/36299/20181121132138517904/k6374_2.pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright(c) by Author
• References (URI): URI; http://www.ojrd.com/content/7/1/99
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 広島大学 : 広島大学学術情報リポジトリ