Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis : Implications for cholangiocarcinogenesis

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Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis : Implications for cholangiocarcinogenesis

Material type: 博士論文

Author: Ishii, Yasutaka

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Name of awarding university/degree: 広島大学(Hiroshima University),博士(医学)

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Note (General)：: type:textCholangiocarcinoma (CCA) occurs frequently in primary sclerosing cholangitis (PSC). Cyclooxygenase-2 (COX-2) and microsomal prostaglandin E s...

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Material Type: 博士論文
Title: Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis : Implications for cholangiocarcinogenesis
Author/Editor: Ishii, Yasutaka
Author Heading: Ishii, Yasutaka
Alternative Title: 原発性硬化性胆管炎ではcyclooxygenase-2とmicrosomal prostaglandin E synathase-1の発現が亢進し、胆管発がんへの関与が示唆される
Degree grantor/type: 広島大学(Hiroshima University)
Date Granted: 2014-03-23
Dissertation Number: 甲第6375号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: primary sclerosing cholangitis
cyclooxygenase-2
microsomal prostaglandin E synthase-1
cholangiocarcinoma
NDC: 490
Target Audience: 一般
Note (General): type:text
Cholangiocarcinoma (CCA) occurs frequently in primary sclerosing cholangitis (PSC). Cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) induced by inflammation are believed to mediate prostaglandin E2 (PGE2) production thereby promoting carcinogenesis. Their expression in PSC-associated CCA tissues and non-neoplastic bile duct epithelial cells (BDECs) in PSC was investigated. COX-2 and mPGES-1 levels in 15 PSC patients (7 with CCA) were scored using immunohistochemical staining. The results were compared with those obtained in CCA tissues and non-neoplastic BDECs (controls) of 15 sporadic CCA patients. Non-neoplastic BDECs from large and small bile ducts were investigated separately. The mRNA expression levels of COX-2 and mPGES-1 in CCA tissues were analyzed by quantitative polymerase chain reaction. Ki-67 immunostaining was performed to evaluate cell proliferation. COX-2 was strongly expressed in PSC-associated CCA tissues and non-neoplastic BDECs in PSC. This expression was significantly upregulated in both compared with sporadic CCA tissues and non-neoplastic BDECs in sporadic CCA (both P<0.01). mPGES-1 was expressed at moderate to strong levels in PSC. Compared with controls, the expression was significantly higher in non-neoplastic small BDECs (P<0.01). COX-2 mRNA levels were significantly higher in PSC-associated tissues than in sporadic CCA tissues (P<0.01). Conversely, no differences were observed in mPGES-1 mRNA levels. Ki-67 labeling indices were higher in PSC-associated CCA tissues and non-neoplastic BDECs in PSC than in controls. In conclusion, COX-2 and mPGES-1 were highly expressed in PSC-associated CCA tissues and non-neoplastic BDECs in PSC, suggesting the involvement of COX-2 and mPGES-1 in cholangiocarcinogenesis.
Format (IMT): application/pdf
Source: fulltext
https://ir.lib.hiroshima-u.ac.jp/files/public/3/36300/20141121014754404352/k6375_3.pdf
fulltext
https://ir.lib.hiroshima-u.ac.jp/files/public/3/36300/20181121132225576320/k6375_1.pdf
fulltext
https://ir.lib.hiroshima-u.ac.jp/files/public/3/36300/2018112113222691022/k6375_2.pdf
Access Restrictions: インターネット公開
Rights (production): Copyright(c) by Author
References (URI): URI
http://dx.doi.org/10.3892/ijo.2013.2038
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 広島大学 : 広島大学学術情報リポジトリ