Association between serum levels of n-3 polyunsaturated fatty acids and coronary plaque detected by coronary computed tomography angiography in patients receiving statin therapy

• Material Type: 博士論文
• Title: Association between serum levels of n-3 polyunsaturated fatty acids and coronary plaque detected by coronary computed tomography angiography in patients receiving statin therapy
• Author/Editor: Urabe, Youji
• Author Heading: Urabe, Youji
• Alternative Title: スタチン治療患者における血清n-3系多価不飽和脂肪酸濃度と冠動脈プラークとの関連性 : 冠動脈CT血管造影による評価
• Degree grantor/type: 広島大学(Hiroshima University)
• Date Granted: 2014-03-23
• Dissertation Number: 甲第6392号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: Coronary computed tomography angiography; Coronary plaques; Eicosapentaenoic acid; N-3 polyunsaturated fatty acid
• NDC: 490
• Target Audience: 一般
• Note (General): type:text; Background: Intensive lipid-lowering therapy with statins reduces cardiovascular events, but residual cardiovascular risks remain. Intake of n-3 polyunsaturated fatty acids (PUFAs) has been associated with cardiovascular events. We examined the relationships between serum n-3 PUFAs and coronary atherosclerotic findings on computed tomography angiography (CTA) in patients undergoing statin treatment. Methods and Results: We enrolled 172 subjects (mean age: 68.2 years; 64% men) prior to statin treatment for 6 months. Serum PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, were measured. When the patients were divided into 2 groups according to the median EPA level (61.3 μg/ml), the low-EPA group showed higher incidences of 3-vessel plaque involvement (62% vs. 43%, P=0.015), noncalcified plaques (NCPs) (74% vs. 52%, P=0.0016), extensive NCPs (?2 segments) (56% vs. 34%, P=0.0036), and high-risk plaques (minimum CT density <39 HU and remodeling index >1.05) (43% vs. 22%, P=0.0034). Multivariate analyses revealed that low EPA levels were an independent factor for these coronary plaque findings. The DHA levels were not independently associated with these findings. Conclusions: Low serum EPA level, but not serum DHA, is associated with the presence and extent of NCPs and high-risk plaques detected by coronary CTA in patients undergoing lipid-lowering therapy with statins.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright(c) by Author
• References (URI): http://dx.doi.org/10.1253/circj.CJ-13-0257; URI
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 広島大学 : 広島大学学術情報リポジトリ

Table of Contents

https://ir.lib.hiroshima-u.ac.jp/files/public/3/36307/20141121015623971895/k6392_3.pdf fulltext

https://ir.lib.hiroshima-u.ac.jp/files/public/3/36307/20181122135518215083/k6392_1.pdf fulltext

https://ir.lib.hiroshima-u.ac.jp/files/public/3/36307/20181122135518698088/k6392_2.pdf fulltext