Maternal estrogen controls retinoic acid metabolism and signaling in early vertebrate development
Digital data available（広島大学学術情報リポジトリ）
Begin reading now
学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
Search by Bookstore
Holdings of Libraries in Japan
This page shows libraries in Japan other than the National Diet Library that hold the material.
Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.
Search by Bookstore
Bibliographic Record
You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.
- Material Type
- 文書・図像類
- Title
- Author/Editor
- Nishinaga, MasanoriOnizuka, Yuh-ichiHanafusa, TakahiroNomiyama, Kei-ichiWatanabe, DaisukeKinashi, ToshifumiMurashige, ToshiakiKunishi, MunehiroHori-e, RyotaHayashida, YasufumiYamashita, Ichirou
- Author Heading
- Pages
- 1-87
- Text Language Code
- eng
- Subject Heading
- Target Audience
- 一般
- Note (General)
- type:textFertilized eggs of lower vertebrates contain substantial amounts of steroidal hormones such as estrogen transferred from mother during oogenesis. However, molecular roles for maternal estrogen in the early embryonic development are largely unknown. Here we show that maternal estrogen and estrogen receptor-α modulate retinoic acid (RA) metabolism and RA-responsive gene expression in medaka embryos. Treatments with excess estradiol, an anti-estrogen (tamoxifen), overexpression or knockdown of estrogen receptor-α (ERα) resulted in misregulation of RA-related gene expression such as raldh2 (retinalaldehyde dehydrogenase), cyp26a1 (RA hydroxylase), fgf8 (fibroblast growth factor), rarα (RA receptor-α), and ahr1 (aryl hydrocarbon receptor). We propose that maternal estrogen/ERα plays a critical role in the feedback control of in vivo level of RA and that it also activates RA signaling for the development of hindbrain and vasculatures. This is the first report demonstrating that maternal estrogen supports successful embryonic development by controlling RA metabolism and signaling in early vertebrate embryos.Supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
- Format (IMT)
- application/pdf