Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide

Digital data available（秋田大学学術情報リポジトリ）

学術機関リポジトリデータベース（IRDB）（機関リポジトリ）

Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide

Material type: 博士論文

Author: 石河, 軌久ほか

Publisher: -

Publication date: 2014-06-01

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 秋田大学,博士（医学）

View All

Notes on use

Note (General)：: Recurrence after chemotherapy is a major cause of cancer mortality: subsets of tumor cells evade initial chemotherapy or radiotherapy and survive to r...

Related materials as well as pre- and post-revision versions

http://hdl.handle.net/10295/2504

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Akita University Institutional Repository
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Akita University Institutional Repository

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Salinomycin sensitizes melanoma spheroids containing slow-cycling cells to the effects of arsenic trioxide
Author/Editor: 石河, 軌久
Ishiga, Norihisa
Author Heading: 石河, 軌久
Ishiga, Norihisa
Publication Date: 2014-06-01
Publication Date (W3CDTF): 2014-06-01
Alternative Title: サリノマイシン細胞周期の遅い細胞を含むメラノーマ・スフェロイドの三酸化ヒ素に対する効果を鋭敏化する
Degree grantor/type: 秋田大学
Date Granted: 2014-03-22
Dissertation Number: 甲第1077号
Degree Type: 博士（医学）
Text Language Code: eng
Target Audience: 一般
Note (General): Recurrence after chemotherapy is a major cause of cancer mortality: subsets of tumor cells evade initial chemotherapy or radiotherapy and survive to re-propagate the tumor. To develop a novel therapeutic approach for melanoma, we applied a non-adhesive culture system which developed spheroids mimicking the properties of melanoma in vivo. Subsequently, spheroids involved cells exhibiting clonogenic and slow-cycling properties in addition to chemotherapeutic resistance to doxorubicin. Interestingly, while treatment of spheroids with either salinomycin or As_2O_3 showed limiting effects, a combinatorial treatment was markedly superior to single treatment with each drug. Thus, melanoma spheroids could be a new platform for studying melanoma biology and are likely to provide a clinically relevant target for the novel chemotherapy.
Access Restrictions: インターネット公開
Related Material: http://hdl.handle.net/10295/2504
http://hdl.handle.net/10295/2504
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 秋田大学 : 秋田大学学術情報リポジトリ