REG Iα Promotes PD-L1 Expression in Esophageal Cancer Cells.

Material type: 博士論文

Author: 脇田, 晃行ほか

Publisher: -

Publication date: 2015-06-01

Material Format: Digital

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Name of awarding university/degree: 秋田大学,博士（医学）

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Note (General)：: Regenerating gene (REG)Iα is known to contribute to carcinogenesis and to be associated with a poor prognosis in various cancers. Programmed death-1 ...

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Material Type: 博士論文
Title: REG Iα Promotes PD-L1 Expression in Esophageal Cancer Cells.
Author/Editor: 脇田, 晃行
WAKITA, Akiyuki
Author Heading: 脇田, 晃行
WAKITA, Akiyuki
Publication Date: 2015-06-01
Publication Date (W3CDTF): 2015-06-01
Alternative Title: 食道扁平上皮癌細胞において REG Iαは PD-L1 の発現を誘導する
Degree grantor/type: 秋田大学
Date Granted: 2015-03-22
Dissertation Number: 甲第1127号
Degree Type: 博士（医学）
Text Language Code: eng
Subject Heading: PD-L1
REG Iα
esophageal cancer
Target Audience: 一般
Note (General): Regenerating gene (REG)Iα is known to contribute to carcinogenesis and to be associated with a poor prognosis in various cancers. Programmed death-1 ligand(PD-L1) is a negative regulator of T cell activation thought to play an important role in tumor evasion from host immunity. In the present study, we tested the hypothesis that the pro-survival effects of REG Iα in cancer reflect enhanced expression of PD-L1. We found that PD-L1 mRNA expression tended to correspond to REG Iα mRNA levels in esophageal squamous cancer cells, and that REG Iα expression significantly increased expression of both PD-L1 mRNA and protein in TE-5 and TE-9 squamous esophageal cancer cells transfected with REG Iα. In addition, immunohistochemical analysis of squamous cell esophageal cancer specimens revealed that the spatial distribution of PD-L1 expression corresponded to that of REG Iα. These findings suggest that REG Iα may suppress antitumor immunity by inducing PD-L1 expression.
Format (IMT): application/pdf
Source: 本文
https://air.repo.nii.ac.jp/record/2556/files/ihakukou1127.pdf
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 秋田大学 : 秋田大学学術情報リポジトリ