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Molecular Mechanism of ATP Hydrolysis in F<sub>1</sub>-ATPase Revealed by Molecular Simulations and Single-Molecule Observations
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Molecular Mechanism of ATP Hydrolysis in F<sub>1</sub>-ATPase Revealed by Molecular Simulations and Single-Molecule Observations
- Material type
- 記事
- Author
- Shigehiko Hayashiほか
- Publisher
- American Chemical Society (ACS)
- Publication date
- 2012-05-11
- Material Format
- Digital
- Journal name
- Journal of the American Chemical Society 134 20
- Publication Page
- p.8447-8454
Detailed bibliographic record
Summary, etc.:
- Enzymatic hydrolysis of nucleotide triphosphate (NTP) plays a pivotal role in protein functions. In spite of its biological significance, however, the...
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Digital
- Material Type
- 記事
- Author Heading
- Publication Date
- 2012-05-11
- Publication Date (W3CDTF)
- 2012-05-11
- Periodical title
- Journal of the American Chemical Society
- No. or year of volume/issue
- 134 20
- Volume
- 134
- Issue
- 20
- Pages
- 8447-8454
- Publication date of volume/issue (W3CDTF)
- 2012-05-11
- ISSN (Periodical Title)
- 00027863
- Publication (Periodical Title)
- American Chemical Society (ACS)
- Subject Heading
- Target Audience
- 一般
- Standard No. (Other)
- PMID : 22548707
- DOI
- 10.1021/ja211027m
- Date Created (W3CDTF)
- 2012-05-01
- Related Material (URI)
- Is Referenced By
- Structures and mechanisms of actin ATP hydrolysisATP hydrolysis assists phosphate release and promotes reaction ordering in F-1-ATPaseCatalytic robustness and torque generation of the F1-ATPaseSingle-Molecule Analysis of the Rotation of F1-ATPase under High Hydrostatic PressureIntersubunit coordination and cooperativity in ring-shaped NTPasesAdenosine Triphosphate Hydrolysis Mechanism in Kinesin Studied by Combined Quantum-Mechanical/Molecular-Mechanical Metadynamics SimulationsMolecular Dynamics Simulations of Yeast F<sub>1</sub>-ATPase before and after 16° Rotation of the γ SubunitStructure and dynamics of rotary V1 motorTorque Transmission Mechanism via DELSEED Loop of F1-ATPaseThermodynamic analysis of <scp>F</scp><sub>1</sub>‐<scp>ATP</scp>ase rotary catalysis using high‐speed imagingMechanism of the αβ Conformational Change in F1-ATPase after ATP Hydrolysis: Free-Energy SimulationsTight Chemomechanical Coupling of the F1 Motor Relies on Structural StabilityDissecting the Dynamics during Enzyme Catalysis: A Case Study of Pin1 Peptidyl-Prolyl IsomeraseRotational mechanism of Enterococcus hirae V1-ATPase by crystal-structure and single-molecule analysesThermodynamic Analyses of Nucleotide Binding to an Isolated Monomeric β Subunit and the α3β3γ Subcomplex of F1-ATPaseRotary catalysis of bovine mitochondrial F <sub>1</sub> -ATPase studied by single-molecule experimentsBiological Nanomotors with a Revolution, Linear, or Rotation Motion MechanismMolecular structure and rotary dynamics of <i><scp>E</scp>nterococcus hirae</i><scp>V</scp><sub>1</sub>‐<scp>ATP</scp>aseMolecular Modeling and Molecular Dynamics Simulations of Recombinase Rad51Key Chemical Factors of Arginine Finger Catalysis of F<sub>1</sub>-ATPase Clarified by an Unnatural Amino Acid MutationRobustness of the Rotary Catalysis Mechanism of F1-ATPaseAtomic-scale origins of slowness in the cyanobacterial circadian clockRotary properties of hybrid F1-ATPases consisting of subunits from different speciesFO-F1 coupling and symmetry mismatch in ATP synthase resolved in every FO rotation stepSpatiotemporal Characteristics Determining the Multifaceted Nature of Reactive Oxygen, Nitrogen, and Sulfur Species in Relation to Proton HomeostasisTheoretical Method of Calculating Solvent Nonequilibrium Effect on Solute MovementKinetic analysis of the inhibition mechanism of bovine mitochondrial F₁-ATPase inhibitory protein using biochemical assay
- References
- Catalysis and rotation of F <sub>1</sub> motor: Cleavage of ATP at the catalytic site occurs in 1 ms before 40° substep rotationOn the Mechanism of ATP Hydrolysis in F1-ATPaseEvidence for an associative mechanism in the phosphoryl transfer step catalyzed by rabbit muscle creatine kinase.General atomic and molecular electronic structure systemQM/MM Reweighting Free Energy SCF for Geometry Optimization on Extensive Free Energy Surface of Enzymatic ReactionSimple Dark-Field Microscopy with Nanometer Spatial Precision and Microsecond Temporal ResolutionOn the Mechanism of Hydrolysis of Phosphate Monoesters Dianions in Solutions and ProteinsDirect observation of the rotation of F1-ATPaseMechanical modulation of catalytic power on F1-ATPaseConverting conformational changes to electrostatic energy in molecular motors: The energetics of ATP synthaseThe Way Things Move: Looking Under the Hood of Molecular Motor ProteinsKinetic isotope effects in Ras-catalyzed GTP hydrolysis: Evidence for a loose transition stateA Structure-Based Model for the Synthesis and Hydrolysis of ATP by F1-ATPasePrincipal Role of the Arginine Finger in Rotary Catalysis of F1-ATPaseMicrosecond Time Scale Rotation Measurements of Single F<sub>1</sub>-ATPase MoleculesMechanical Rotation of the c Subunit Oligomer in ATP Synthase (F <sub>0</sub> F <sub>1</sub> ): Direct ObservationROTATIONAL COUPLING IN THE F<sub>0</sub>F<sub>1</sub> ATP SYNTHASEProton-powered subunit rotation in single membrane-bound F0F1-ATP synthasePartial rigid‐body dynamics in NPT, NPAT and NPγT ensembles for proteins and membranesG PROTEIN MECHANISMS: Insights from Structural AnalysisCorrelation between the conformational states of F <sub>1</sub> -ATPase as determined from its crystal structure and single-molecule rotationPyruvate kinase: is the mechanism of phospho transfer associative or dissociative?Further examination of seventeen mutations in Escherichia coli F1-ATPase beta-subunit.Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPasePhosphate release in F1-ATPase catalytic cycle follows ADP releaseThe cysteine introduced into the alpha subunit of the Escherichia coli F1-ATPase by the mutation alpha R376C is near the alpha-beta subunit interface and close to a noncatalytic nucleotide binding site.Spatial precision of a catalytic carboxylate of F<sub>1</sub>‐ATPase β subunit probed by introducing different carboxylate‐containing side chainsMechanochemical Coupling in Myosin: A Theoretical Analysis with Molecular Dynamics and Combined QM/MM Reaction Path CalculationsF1-ATPase rotates by an asymmetric, sequential mechanism using all three catalytic subunitsLinkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pairWhy have mutagenesis studies not located the general base in ras p21ATP Hydrolysis in the βTP and βDP Catalytic Sites of F1-ATPaseProton Transfer in Bacteriorhodopsin: Structure, Excitation, IR Spectra, and Potential Energy Surface Analyses by an ab Initio QM/MM MethodRotation of F<sub>1</sub>-ATPase: How an ATP-Driven Molecular Machine May WorkCoupling of Rotation and Catalysis in F1-ATPase Revealed by Single-Molecule Imaging and ManipulationMutational replacements of conserved amino acid residues in the α subunit change the catalytic properties of Escherichia coli F1-ATPaseRas-catalyzed hydrolysis of GTP: a new perspective from model studies.F1-ATPase Is a Highly Efficient Molecular Motor that Rotates with Discrete 120° StepsConserved Glu-181 and Arg-182 Residues of Escherichia coli H+-ATPase (ATP Synthase) β Subunit Are Essential for Catalysis: Properties of 33 Mutants between βGlu-161 and βLys-201 Residues1ATP synthase — a marvellous rotary engine of the cellExtensive Conformational Transitions Are Required to Turn On ATP Hydrolysis in MyosinMechanisms of guanosine triphosphate hydrolysis by Ras and Ras‐GAP proteins as rationalized by ab initio QM/MM simulationsMechanism of the myosin catalyzed hydrolysis of ATP as rationalized by molecular modelingRole of α-Subunit VISIT-DG Sequence Residues Ser-347 and Gly-351 in the Catalytic Sites of Escherichia coli ATP SynthaseCooperative three-step motions in catalytic subunits of F1-ATPase correlate with 80° and 40° substep rotationsOn the Myosin Catalysis of ATP HydrolysisCatalytic mechanism of F1-ATPaseABC transporters: a riddle wrapped in a mystery inside an enigmaStructure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondriaDouble-lock ratchet mechanism revealing the role of αSER-344 in F <sub>o</sub> F <sub>1</sub> ATP synthaseGround State Structure of F1-ATPase from Bovine Heart Mitochondria at 1.9 Aå ResolutionTorque generation and elastic power transmission in the rotary FOF1-ATPase
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