Molecular mechanisms underlying the promotion of wound repair by coenzyme Q10: PI3K/Akt signal activation via alterations to cell membrane domains

• Material Type: 記事
• Title: Molecular mechanisms underlying the promotion of wound repair by coenzyme Q10: PI3K/Akt signal activation via alterations to cell membrane domains
• Author Heading: Kurashiki Tatsuyuki; Horikoshi Yosuke; https://orcid.org/0000-0001-6587-644X; Kamizaki Koki; Sunaguchi Teppei; Hara Kazushi; Morimoto Masaki; Kitagawa Yoshinori; Nakaso Kazuhiro; Otsuki Akihiro; Matsura Tatsuya
• Publication Date: 2022
• Publication Date (W3CDTF): 2022
• Periodical title: Ｊ． Ｃｌｉｎ． Ｂｉｏｃｈｅｍ． Ｎｕｔｒ．
• No. or year of volume/issue: 70 3
• Volume: 70
• Issue: 3
• Pages: 222-230
• Publication date of volume/issue (W3CDTF): 2022
• ISSN (Periodical Title): 09120009
• Publication (Periodical Title): SOCIETY FOR FREE RADICAL RESEARCH JAPAN
• Text Language Code: en
• Subject Heading: coenzyme Q10; wound healing; PI3K/Akt signaling; caveolin-1; membrane domains
• Target Audience: 一般
• Standard No. (Other): PMID : 35692678
• DOI: 10.3164/jcbn.21-141
• Related Material (URI): https://www.jstage.jst.go.jp/article/jcbn/70/3/70_21-141/_pdf; https://search.jamas.or.jp/link/ui/2023214096
• References: Oxidative stress-induced activation of Abl and Src kinases rapidly induces P-glycoprotein internalization via phosphorylation of caveolin-1 on tyrosine-14, decreasing cortisol efflux at the blood–brain barrier; https://cir.nii.ac.jp/crid/1360004236645414400; Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT; https://cir.nii.ac.jp/crid/1360011143787372160; Role of growth factors and biomaterials in wound healing; https://cir.nii.ac.jp/crid/1360011144741767296; Application of Coenzyme Q10 for Accelerating Soft Tissue Wound Healing after Tooth Extraction in Rats; https://cir.nii.ac.jp/crid/1360285714488324992; Metastasis and chemoresistance in CD133 expressing pancreatic cancer cells are dependent on their lipid raft integrity; https://cir.nii.ac.jp/crid/1360292618615836288; Topical Delivery of Coenzyme Q10-Loaded Microemulsion for Skin Regeneration; https://cir.nii.ac.jp/crid/1360292620637977728; A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish; https://cir.nii.ac.jp/crid/1360292621281536000; Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex; https://cir.nii.ac.jp/crid/1360567184450002816; Functional connections and pathways of coenzyme Q10‐inducible genes: An in‐silico study; https://cir.nii.ac.jp/crid/1360574094538660736; Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells; https://cir.nii.ac.jp/crid/1360574094580608000; α‐Tocopherol promotes HaCaT keratinocyte wound repair through the regulation of polarity proteins leading to the polarized cell migration; https://cir.nii.ac.jp/crid/1360846639377371904; Long-Term Survival of Patients Receiving Artificial Nutrition in Japanese Psychiatric Hospitals; https://cir.nii.ac.jp/crid/1360848661337156224; Golgi Positioning; https://cir.nii.ac.jp/crid/1360855568963347712; Inhibition of Akt Signaling by Exclusion from Lipid Rafts in Normal and Transformed Epidermal Keratinocytes; https://cir.nii.ac.jp/crid/1360855568970883072; Effects of Hydrogen Peroxide on Wound Healing in Mice in Relation to Oxidative Damage; https://cir.nii.ac.jp/crid/1360855571357373056; Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases; https://cir.nii.ac.jp/crid/1361137043760035200; Metabolism and function of coenzyme Q; https://cir.nii.ac.jp/crid/1361137043858274944; The Golgi apparatus and cell polarity: Roles of the cytoskeleton, the Golgi matrix, and Golgi membranes; https://cir.nii.ac.jp/crid/1361137044258764800; Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells; https://cir.nii.ac.jp/crid/1361137044788033152; Spatiotemporal Analysis of Differential Akt Regulation in Plasma Membrane Microdomains; https://cir.nii.ac.jp/crid/1361418518710446464; Cytoskeletal Crosstalk in Cell Migration; https://cir.nii.ac.jp/crid/1361418518781961600; Additive enhancement of wound healing in diabetic mice by low level light and topical CoQ10; https://cir.nii.ac.jp/crid/1361418519703889024; Nutrition; https://cir.nii.ac.jp/crid/1361418520071997696; Tight Junction, a Platform for Trafficking and Signaling Protein Complexes; https://cir.nii.ac.jp/crid/1361418521111134080; The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders; https://cir.nii.ac.jp/crid/1361418521470442752; Review of the Current Management of Pressure Ulcers; https://cir.nii.ac.jp/crid/1361699994337028480; Co-Regulation of Cell Polarization and Migration by Caveolar Proteins PTRF/Cavin-1 and Caveolin-1; https://cir.nii.ac.jp/crid/1361981468976321792; Caveolin‐1 influences epithelial collective cell migration via FMNL2 formin; https://cir.nii.ac.jp/crid/1361981469121408128; The Inhibition of Mitochondrial Peroxidation by Ubiquinone and Ubiquinol; https://cir.nii.ac.jp/crid/1361981470640650496; The newly found functions of MTOC in immunological response; https://cir.nii.ac.jp/crid/1361981471030336512; Protective effects of coenzyme Q₁₀and α-tocopherol against free radical-mediated liver cell injury; https://cir.nii.ac.jp/crid/1362262944455662976; aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region; https://cir.nii.ac.jp/crid/1362262944642083072; The RNA-binding protein HuR regulates intestinal epithelial restitution by modulating Caveolin-1 gene expression; https://cir.nii.ac.jp/crid/1362262946299592704; Polarity proteins in migration and invasion; https://cir.nii.ac.jp/crid/1362544418666612096; Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation; https://cir.nii.ac.jp/crid/1362544418919207936; Structure and function of the epidermis related to barrier properties; https://cir.nii.ac.jp/crid/1362825894313726720; Delivery of raft-associated, GPI-anchored proteins to the apical surface of polarized MDCK cells by a transcytotic pathway; https://cir.nii.ac.jp/crid/1362825894735574656; Acetaminophen-induced hepatic injury in mice: The role of lipid peroxidation and effects of pretreatment with coenzyme Q10 and α-tocopherol; https://cir.nii.ac.jp/crid/1362825895825700096; Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure; https://cir.nii.ac.jp/crid/1363107369454417152; Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching; https://cir.nii.ac.jp/crid/1363107370863726336; From cells to organs: building polarized tissue; https://cir.nii.ac.jp/crid/1363388843838607232; AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer; https://cir.nii.ac.jp/crid/1363388844340147200; Membrane microviscosity regulates endothelial cell motility; https://cir.nii.ac.jp/crid/1363388844793475328; PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing; https://cir.nii.ac.jp/crid/1363388846253258752; Difference in antioxidant activity between reduced coenzyme Q9 and reduced coenzyme Q10 in the cell: studies with isolated rat and guinea pig hepatocytes treated with a water-soluble radical initiator; https://cir.nii.ac.jp/crid/1363951794790275200; Interaction between PAR-3 and the aPKC–PAR-6 complex is indispensable for apical domain development of epithelial cells; https://cir.nii.ac.jp/crid/1363951795075129216; A role for caveolae in cell migration; https://cir.nii.ac.jp/crid/1364233268247177472; Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells; https://cir.nii.ac.jp/crid/1364233268585478144; Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis <i>in vivo</i>; https://cir.nii.ac.jp/crid/1364233269316956032; Effects of coenzyme Q10 encapsulated in nanoliposomes on wound healing processes after tooth extraction; https://cir.nii.ac.jp/crid/1364233269503833984; Pressure ulcer prevalence in Europe: a pilot study; https://cir.nii.ac.jp/crid/1364233269563324288; Studies with Ubiquinone‐Depleted Submitochondrial Particles; https://cir.nii.ac.jp/crid/1364233270421664896; Prosaposin knockdown in Caco-2 cells decreases cellular levels of coenzyme Q10 and ATP, and results in the loss of tight junction barriers; https://cir.nii.ac.jp/crid/1390001204672906368; Protection by Exogenously Added Coenzyme Q9 against Free Radical-Induced Injuries in Human Liver Cells; https://cir.nii.ac.jp/crid/1390001204673444736; Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome.; https://cir.nii.ac.jp/crid/1390282681297511808; Suppressive effects of quercetin on hydrogen peroxide-induced caveolin-1 phosphorylation in endothelial cells; https://cir.nii.ac.jp/crid/1390570022236310784
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; Crossref; https://www.crossref.org; CiNii Articles; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja
• NAID: 130008140083

• Summary, etc.: <p>Coenzyme Q10 (CoQ10) promotes wound healing <i>in vitro</i> and <i>in vivo</i>. However, the molecular mechanisms underlying the promoting effects ...