Ganoderic Acid A Promotes Amyloid-β Clearance (In Vitro) and Ameliorates Cognitive Deficiency in Alzheimer’s Disease (Mouse Model) through Autophagy Induced by Activating Axl

• Material Type: 記事
• Title: Ganoderic Acid A Promotes Amyloid-β Clearance (In Vitro) and Ameliorates Cognitive Deficiency in Alzheimer’s Disease (Mouse Model) through Autophagy Induced by Activating Axl
• Author Heading: Li-Feng-Rong Qi; Shuai Liu; Yu-Ci Liu; Ping Li; Xiaojun Xu; https://orcid.org/0000-0003-4379-8748
• Publication Date: 2021-05-24
• Publication Date (W3CDTF): 2021-05-24
• Periodical title: International Journal of Molecular Sciences
• No. or year of volume/issue: 22
• Volume: 22
• Pages: 5559-
• Publication date of volume/issue (W3CDTF): 2021-05-24
• Publication (Periodical Title): MDPI AG
• Subject Heading: Male; Hippocampus; Cell Line; Lanosterol; Mice; Alzheimer Disease; Morris Water Maze Test; Proto-Oncogene Proteins; Autophagy; Animals; Phosphorylation; Amyloid beta-Peptides; Alzheimer’s disease; amyloid β; ganoderic acid A; autophagy; Axl; Autophagosomes; Receptor Protein-Tyrosine Kinases; Immunohistochemistry; Axl Receptor Tyrosine Kinase; Mice, Inbred C57BL; Disease Models, Animal; p21-Activated Kinases; Heptanoic Acids; Microglia; Lysosomes; Signal Transduction
• Target Audience: 一般
• Standard No. (Other): PMID : 34074054
• DOI: 10.3390/ijms22115559; https://doi.org/10.3390/ijms22115559
• Access Restrictions: インターネット公開
• References: Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice; https://cir.nii.ac.jp/crid/1881428067454457088; Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion; https://cir.nii.ac.jp/crid/1884242817876532352
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/

• Summary, etc.: <jats:p>Alzheimer’s disease (AD) is thought to be caused by amyloid-β (Aβ) accumulation in the central nervous system due to deficient clearance. The ...