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Asciminib, a novel allosteric inhibitor of BCR-ABL1, shows synergistic effects when used in combination with imatinib with or without drug resistance

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岡本, 尚大, 八木, 健太, Imawaka, Sayaka, Takaoka, Mayu, 相澤, 風花, 新村, 貴博, 合田, 光寛, Miyata, Koji, 川田, 敬, (井澤)石澤, 有紀, 坂口, 暁, 石澤, 啓介British Pharmacological Society2024-06-21Pharmacology Research & Perspectives12 4p.e1214-

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Summary, etc....cy. Therefore, asciminib was introduced......-ABL inhibitor asciminib and convention......combination of asciminib and imatinib. ......f imatinib and asciminib exposure on ce......n imatinib and asciminib were combined ......s of action of asciminib. Asciminib in combination......inhibitors and asciminib may occur, which needs to be ...
Subject HeadingCML chronic myelogenous leukemia Asciminib BCR-ABL inhibitors Drug Resis...

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