Search results 3
Digital博士論文
National Diet Library
- Subject HeadingRRM1 shRNA Adenovirus Gene therapy...
- Note (General)...large subunit (RRM1) is the main e......rexpression of RRM1 is reportedly ......herapy against RRM1-overexpressing...... targeting the RRM1 gene (Ad-shRRM1) was constructed. Two RRM1-overexpressing...... Results: Ad-shRRM1 effectively downregulated RRM1 mRNA and prote......ection with Ad-RRM1 increased the ......either type of RRM1-overexpressing......ment with Ad-shRRM1 exerted a pote......ct against the RRM1-overexpressing......thermore, Ad-shRRM1-mediated inhibition of RRM1 specifically i......f each type of RRM1-overexpressing......ment with Ad-shRRM1 and GEM exerte......tion than Ad-shRRM1 or GEM treatment alone. Concl...
Digital博士論文障害者向け資料あり
National Diet Library
- Subject Heading肝内胆管癌 Gemcitabine RRM1 術前化学療法 外科切除
- Note (General)...Reductase M1(以下RRM1)はGEMの作用機序に重要な働......究の目的は,肝内胆管癌におけるRRM1発現を免疫組織化学にて検討し,......EM基盤の術前化学療法の効果とRRM1発現との関連を明らかにすること......ガイドラインに準じて判定した.RRM1発現は免疫組織化学により評価さ......または陰性に分類した.【結果】RRM1発現陽性は43例中27例(63......化学療法を施行した4例中3例はRRM1発現陽性であり,腫瘍縮小率は1......SD)と判定された.残り1例はRRM1発現陰性で,腫瘍縮小率は68%......EM基盤の術前化学療法の効果はRRM1発現と関連していることが示唆される.高度局所進展を伴う肝内胆...
Digital博士論文
Available onlineOther Libraries in Japan
- Subject HeadingRRM1 shRNA Adenovirus Gene therapy...
Reached to the end of result.