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- 件名ミネラルコルチコイド受容体,転写共役因子,GWAS解析,ヒストンメチル化修飾酵素,Evi-1
- 一般注記...探索を行い, その中の候補因子Evi-1の解析を行った。Evi-1はヒストンメチル化活性を有する......メインを分子内に持ち, 全長のEvi-1cはMR転写を抑制性に制御する......もう1つのアイソフォームであるEvi-1aはdominant nega...... been focused. Evi-1 was identified......eening method. Evi-1 has SET domain......hole molecule "Evi-1c", but another isoform "Evi-1a", which lacks......t negative for Evi-1c. This study elucidated that Evi-1c functions as ......-expression of Evi-1a suppresses the activity of Evi-1c. The recent G......certain SNP of Evi-1 gene is associ......e the ratio of Evi-1c/Evi-1a, leading to the change of MR...