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A novel chemogenetic agnoist "Deschloroclozapine" selectively visualizes and activates chemogenetic receptors in non-human primates

A novel chemogenetic agnoist "Deschloroclozapine" selectively visualizes and activates chemogenetic receptors in non-human primates
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永井, 裕司, 宮川, 尚久, 堀, 由紀子, 南本, 敬史, Nagai, Yuji, Miyakawa, Naohisa, Hori, Yukiko, Minamimoto, Takafumi2020-02-05
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  • 要約等DREADDs (Designer Receptors Exclusively Ac......odified G-protein coupled receptors that are activ......hysiologically inert designer dr......types of muscarinic-based design......q (excitatory) and hM4Di (inhibitory), are widely used and remotely modul......ulation expressing a "designer r......ith [11C]clozapine enables us to......4Di expression and the agonist do......vides critical information for successful chemogenetic silencing (Nagai et al.......ow selectivity and poor metabolic......ped a novel ligand, deschloroclozapine (DCZ), served a dual purpose in chemogenetics: (1) as a sel......ADD expression in vivo by PET and (2) as a sele...
  • 著者標目永井, 裕司 宮川, 尚久 堀, 由紀子 南本, 敬史 Nagai, Yuji Miyakawa, Naohisa Hori, Yukiko Minamimoto, Takafumi

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