Relationship between Serum TNF Activity and Insulin Resistance in Dairy Cows Affected with Naturally Occurring Fatty Liver

• 資料種別: 記事
• タイトル: Relationship between Serum TNF Activity and Insulin Resistance in Dairy Cows Affected with Naturally Occurring Fatty Liver
• 著者・編者: 大塚 浩通; 小岩 政照; 初谷 敦 他
• 著者標目: 大塚 浩通; 小岩 政照; 初谷 敦
• 並列タイトル等: 乳牛の脂肪肝における血清TNF活性とインスリン抵抗性の関連
• タイトル（掲載誌）: The journal of veterinary medical science = 日本獣醫學会会誌
• 巻号年月日等（掲載誌）: 63(9) 2001.9
• 掲載巻: 63
• 掲載号: 9
• 掲載ページ: 1021～1025
• 掲載年月日（W3CDTF）: 2001-09
• ISSN（掲載誌）: 0916-7250
• ISSN-L（掲載誌）: 0916-7250
• 出版事項（掲載誌）: 東京 : 日本獣医学会
• 出版地（国名コード）: JP
• 本文の言語コード: eng
• NDLC: ZR22
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z18-350
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 5938492; http://id.ndl.go.jp/bib/5938492
• 整理区分コード: 632

• 要約等: To clarify the relationship between tumor necrosis factor (TNF) and insulin resistance in dairy cows affected with fatty liver, naturally occurring cases were investigated. The affected cows were classified into following three groups according to histopathologic findings of the liver: mild fat droplet deposition (group 1; n=11), severe fat droplet deposition (group 2; n=10), and cloudy swelling (group 3; n=8). Serum TNF activities in Group 2 (8.67 ± 2.16 U/m<i>l</i>) and Group 3 (11.65 ± 1.92 U/m<i>l</i>) were significantly higher than that in Group 1 (3.57 ± 0.81 U/m<i>l</i>) (p<0.05). The insulin-tolerance tests showed that the insulin-stimulated glucose disposal rates (GDR) in Group 2 (27.6 ± 7.8%) and Group 3 (15.8 ± 9.1%) were significantly lower than that in Group 1 (41.7 ± 9.8%). There was a significant negative correlation between serum TNF activity and GDR in affected cows (r=-0.56, p<0.01). These results indicate that serum TNF activity is correlated with insulin resistance in cows with fatty liver.
• DOI: 10.1292/jvms.63.1021
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: To clarify the relationship between tumor necrosis factor (TNF) and insulin resistance in dairy cows affected with fatty liver, naturally occurring cases were investigated. The affected cows were classified into following three groups according to histopathologic findings of the liver: mild fat droplet deposition (group 1; n=11), severe fat droplet deposition (group 2; n=10), and cloudy swelling (group 3; n=8). Serum TNF activities in Group 2 (8.67 ± 2.16 U/m<i>l</i>) and Group 3 (11.65 ± 1.92 U/m<i>l</i>) were significantly higher than that in Group 1 (3.57 ± 0.81 U/m<i>l</i>) (p<0.05). The insulin-tolerance tests showed that the insulin-stimulated glucose disposal rates (GDR) in Group 2 (27.6 ± 7.8%) and Group 3 (15.8 ± 9.1%) were significantly lower than that in Group 1 (41.7 ± 9.8%). There was a significant negative correlation between serum TNF activity and GDR in affected cows (r=-0.56, p<0.01). These results indicate that serum TNF activity is correlated with insulin resistance in cows with fatty liver.
• DOI: 10.1292/jvms.63.1021; https://doi.org/10.1292/jvms.63.1021
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（URI）: http://id.ndl.go.jp/bib/5938492; https://ndlsearch.ndl.go.jp/books/R000000004-I5938492; http://www.jstage.jst.go.jp/article/jvms/63/9/63_9_1021/_pdf; https://search.jamas.or.jp/link/ui/2002080990
• 参照: 周産期疾病発生牛群に対する免疫プロファイルテストの有用性; https://cir.nii.ac.jp/crid/1390001205192869504; Slow Recovery of Blood Glucose in the Insulin Tolerance Test during the Prepartum Transition Period Negatively Impacts the Nutritional Status and Reproductive Performance Postpartum of Dairy Cows; https://cir.nii.ac.jp/crid/1390001206428646528; Relationship between the degree of insulin resistance during late gestation and postpartum performance in dairy cows and factors that affect growth and metabolic status of their calves; https://cir.nii.ac.jp/crid/1390001206430704128; 乳牛における潜在性ルーメンアシドーシス（SARA）に関する研究; https://cir.nii.ac.jp/crid/1390020984102101120; Influence of hepatic load from far-off dry period to early postpartum period on the first postpartum ovulation and accompanying subsequent fertility in dairy cows; https://cir.nii.ac.jp/crid/1390282681314349440; 乳牛の周産期に発生した肝脂肪化と血清中遊離アミノ酸濃度; https://cir.nii.ac.jp/crid/1390282681402389504; Comparison of the Insulin Reaction of Peripheral Blood T Cells between Healthy Holstein Dairy Cows and JB during the Periparturient Period; https://cir.nii.ac.jp/crid/1390282681404889216; Internal medicine: Effect of hoof trimming before the dry period on productive performance in perinatal dairy cows; https://cir.nii.ac.jp/crid/1390282681406383232; Internal medicine: Relationship between plasma vitamin C and serum diagnostic biochemical markers in lactating cows; https://cir.nii.ac.jp/crid/1390282681408000000
• 参照: Increased Milk Production Versus Reproductive and Energy Status of High Producing Dairy Cows; https://cir.nii.ac.jp/crid/1360011143869032576; Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output; https://cir.nii.ac.jp/crid/1360292619003084160; Protection from obesity-induced insulin resistance in mice lacking TNF-α function; https://cir.nii.ac.jp/crid/1360292620471195136; Metabolic Characteristics of Induced Ketosis in Normal and Obese Dairy Cows; https://cir.nii.ac.jp/crid/1360292620943757440; Ultrastructural changes of the liver in spontaneously ketotic cows; https://cir.nii.ac.jp/crid/1361699996163567872; TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone; https://cir.nii.ac.jp/crid/1361981468519397376; Plasma Glucose Clearance and Insulin Response in Cows with Abomasal Displacement*; https://cir.nii.ac.jp/crid/1361981471173822336; Metabolic Changes in Blood and Liver During Development and Early Treatment of Experimental Fatty Liver and Ketosis in Cows; https://cir.nii.ac.jp/crid/1362262945378538624; Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.; https://cir.nii.ac.jp/crid/1363107370143968896; A Body Condition Scoring Chart for Holstein Dairy Cows; https://cir.nii.ac.jp/crid/1363388844796809856; Impaired Glucose Tolerance and Heterogeneity of Insulin Responses in Cows with Abomasal Displacement; https://cir.nii.ac.jp/crid/1363951793519459968; Primary Ketosis in the High-Producing Dairy Cow: Clinical and Subclinical Disorders, Treatment, Prevention, and Outlook; https://cir.nii.ac.jp/crid/1363951794014622464; Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.; https://cir.nii.ac.jp/crid/1363951795376644224
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; PubMed; https://pubmed.ncbi.nlm.nih.gov; CiNii Articles
• 書誌ID（NDLBibID）: 5938492; http://id.ndl.go.jp/bib/5938492
• NII論文ID: 110003920739