High-Performance Liquid Chromatographic Assay of Clonazepam in Human Plasma Using a Non-porous Silica Column

• 資料種別: 記事
• タイトル: High-Performance Liquid Chromatographic Assay of Clonazepam in Human Plasma Using a Non-porous Silica Column
• 著者・編者: Mitsuhiro Nakamura; Kana Fukawa; Tadashi Sugiyama 他
• 著者標目: Mitsuhiro Nakamura; Kana Fukawa; Tadashi Sugiyama
• タイトル（掲載誌）: Biological and pharmaceutical bulletin
• 巻号年月日等（掲載誌）: 27(6) 2004.6
• 掲載巻: 27
• 掲載号: 6
• 掲載ページ: 893～895
• 掲載年月日（W3CDTF）: 2004-06
• ISSN（掲載誌）: 0918-6158
• ISSN-L（掲載誌）: 0918-6158
• 出版事項（掲載誌）: Tokyo : Pharmaceutical Society of Japan
• 出版地（国名コード）: JP
• 本文の言語コード: eng
• 件名標目: clonazepam; non-porous silica column; HPLC; benzodiazepine; column extraction
• NDLC: ZS51
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z53-V41
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 6952298; http://id.ndl.go.jp/bib/6952298
• 整理区分コード: 632

• 要約等: A new HPLC method has been developed for measuring clonazepam (CZP) in plasma, using a reversed-phase non-porous silica column packed with 2 μm particles. CZP in plasma was first purified with a column extraction technique and injected onto a non-porous silica column. The calibration curve was linear from 5—200 ng/ml. The recoveries of CZP added to plasma were more than 94.0%, with a coefficient of variation in the range of 5.1—13.8%. We developed a rapid routine method using a non-porous silica column that was accurate and improved solvent consumption in the measurement of CZP.
• DOI: 10.1248/bpb.27.893
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: A new HPLC method has been developed for measuring clonazepam (CZP) in plasma, using a reversed-phase non-porous silica column packed with 2 μm particles. CZP in plasma was first purified with a column extraction technique and injected onto a non-porous silica column. The calibration curve was linear from 5—200 ng/ml. The recoveries of CZP added to plasma were more than 94.0%, with a coefficient of variation in the range of 5.1—13.8%. We developed a rapid routine method using a non-porous silica column that was accurate and improved solvent consumption in the measurement of CZP.
• DOI: 10.1248/bpb.27.893; https://doi.org/10.1248/bpb.27.893
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（URI）: http://id.ndl.go.jp/bib/6952298; https://ndlsearch.ndl.go.jp/books/R000000004-I6952298; http://www.jstage.jst.go.jp/article/bpb/27/6/27_6_893/_pdf; https://search.jamas.or.jp/link/ui/2004283001
• 参照: Improved selectivity for high-performance liquid chromatographic determination of clonazepam in plasma of epileptic patients; https://cir.nii.ac.jp/crid/1360011143567917696; Clonazepam pharmacokinetics and therapeutic efficacy in neonatal seizures; https://cir.nii.ac.jp/crid/1360292618550282112; Determination of Clonazepam in Serum by High Performance Liquid Chromatography; https://cir.nii.ac.jp/crid/1360574093624629760; Simple and Specific High Performance Liquid Chromatographic Method for the Routine Monitoring of Clonazepam in Plasma; https://cir.nii.ac.jp/crid/1360574095230892928; Liquid Chromatographic Assay for Serum Clonazepam; https://cir.nii.ac.jp/crid/1360574095984906112; Study of conformational effects of recombinant interferon γ adsorbed on a non-porous reversed-phase silica support; https://cir.nii.ac.jp/crid/1360855568631188224; Determination of Ro 48-3656 in rat plasma by reversed-phase high-performance liquid chromatography; https://cir.nii.ac.jp/crid/1361418519149972352; Clonazepam; https://cir.nii.ac.jp/crid/1361699994724601984; Analysis of clonazepam in a tablet dosage form using smallbore HPLC; https://cir.nii.ac.jp/crid/1361981469480579840; Quantitation of clonazepam and its 7-amino and 7-acetamido metabolites in plasma by high-performance liquid chromatography; https://cir.nii.ac.jp/crid/1362544418339071232; High-performance liquid chromatographic assay of zonisamide in human plasma using a non-porous silica column; https://cir.nii.ac.jp/crid/1363107368652086784; Evaluation of advanced silica packings for the separation of biopolymers by high-performance liquid chromatography; https://cir.nii.ac.jp/crid/1364233270779956352; High-performance liquid chromatography of amino acids, peptides and proteins; https://cir.nii.ac.jp/crid/1364233271001591168
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; PubMed; https://pubmed.ncbi.nlm.nih.gov; CiNii Articles
• 書誌ID（NDLBibID）: 6952298; http://id.ndl.go.jp/bib/6952298
• NII論文ID: 110003608878