High-Performance Liquid Chromatographic Assay of Clonazepam in Human Plasma Using a Non-porous Silica Column

• Material Type: 記事
• Title: High-Performance Liquid Chromatographic Assay of Clonazepam in Human Plasma Using a Non-porous Silica Column
• Author/Editor: Mitsuhiro Nakamura; Kana Fukawa; Tadashi Sugiyama 他
• Author Heading: Mitsuhiro Nakamura; Kana Fukawa; Tadashi Sugiyama
• Periodical title: Biological and pharmaceutical bulletin
• No. or year of volume/issue: 27(6) 2004.6
• Volume: 27
• Issue: 6
• Pages: 893～895
• Publication date of volume/issue (W3CDTF): 2004-06
• ISSN (Periodical Title): 0918-6158
• ISSN-L (Periodical Title): 0918-6158
• Publication (Periodical Title): Tokyo : Pharmaceutical Society of Japan
• Place of Publication (Country Code): JP
• Text Language Code: eng
• Subject Heading: clonazepam; non-porous silica column; HPLC; benzodiazepine; column extraction
• NDLC: ZS51
• Target Audience: 一般
• Holding library: 国立国会図書館
• Call No.: Z53-V41
• Data Provider (Database): 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• Bibliographic ID (NDL): 6952298; http://id.ndl.go.jp/bib/6952298
• Bibliographic Record Category (NDL): 632

• Summary, etc.: A new HPLC method has been developed for measuring clonazepam (CZP) in plasma, using a reversed-phase non-porous silica column packed with 2 μm particles. CZP in plasma was first purified with a column extraction technique and injected onto a non-porous silica column. The calibration curve was linear from 5—200 ng/ml. The recoveries of CZP added to plasma were more than 94.0%, with a coefficient of variation in the range of 5.1—13.8%. We developed a rapid routine method using a non-porous silica column that was accurate and improved solvent consumption in the measurement of CZP.
• DOI: 10.1248/bpb.27.893
• Access Restrictions: インターネット公開
• Data Provider (Database): 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• Summary, etc.: A new HPLC method has been developed for measuring clonazepam (CZP) in plasma, using a reversed-phase non-porous silica column packed with 2 μm particles. CZP in plasma was first purified with a column extraction technique and injected onto a non-porous silica column. The calibration curve was linear from 5—200 ng/ml. The recoveries of CZP added to plasma were more than 94.0%, with a coefficient of variation in the range of 5.1—13.8%. We developed a rapid routine method using a non-porous silica column that was accurate and improved solvent consumption in the measurement of CZP.
• DOI: 10.1248/bpb.27.893; https://doi.org/10.1248/bpb.27.893
• Access Restrictions: インターネット公開
• Related Material (URI): http://id.ndl.go.jp/bib/6952298; https://ndlsearch.ndl.go.jp/books/R000000004-I6952298; http://www.jstage.jst.go.jp/article/bpb/27/6/27_6_893/_pdf; https://search.jamas.or.jp/link/ui/2004283001
• References: Improved selectivity for high-performance liquid chromatographic determination of clonazepam in plasma of epileptic patients; https://cir.nii.ac.jp/crid/1360011143567917696; Clonazepam pharmacokinetics and therapeutic efficacy in neonatal seizures; https://cir.nii.ac.jp/crid/1360292618550282112; Determination of Clonazepam in Serum by High Performance Liquid Chromatography; https://cir.nii.ac.jp/crid/1360574093624629760; Simple and Specific High Performance Liquid Chromatographic Method for the Routine Monitoring of Clonazepam in Plasma; https://cir.nii.ac.jp/crid/1360574095230892928; Liquid Chromatographic Assay for Serum Clonazepam; https://cir.nii.ac.jp/crid/1360574095984906112; Study of conformational effects of recombinant interferon γ adsorbed on a non-porous reversed-phase silica support; https://cir.nii.ac.jp/crid/1360855568631188224; Determination of Ro 48-3656 in rat plasma by reversed-phase high-performance liquid chromatography; https://cir.nii.ac.jp/crid/1361418519149972352; Clonazepam; https://cir.nii.ac.jp/crid/1361699994724601984; Analysis of clonazepam in a tablet dosage form using smallbore HPLC; https://cir.nii.ac.jp/crid/1361981469480579840; Quantitation of clonazepam and its 7-amino and 7-acetamido metabolites in plasma by high-performance liquid chromatography; https://cir.nii.ac.jp/crid/1362544418339071232; High-performance liquid chromatographic assay of zonisamide in human plasma using a non-porous silica column; https://cir.nii.ac.jp/crid/1363107368652086784; Evaluation of advanced silica packings for the separation of biopolymers by high-performance liquid chromatography; https://cir.nii.ac.jp/crid/1364233270779956352; High-performance liquid chromatography of amino acids, peptides and proteins; https://cir.nii.ac.jp/crid/1364233271001591168
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; PubMed; https://pubmed.ncbi.nlm.nih.gov; CiNii Articles
• Bibliographic ID (NDL): 6952298; http://id.ndl.go.jp/bib/6952298
• NAID: 110003608878