細菌由来複合糖質の合成と自然免疫研究
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- 資料種別
- 記事
- 著者・編者
- 深瀬 浩一藤本 ゆかり下山 敦史 他
- 並列タイトル等
- Synthesis of Bacterial Glycoconjugates and Their Bio-functional Studies in Innate Immunity
- タイトル（掲載誌）
- 有機合成化学協会誌 = Journal of synthetic organic chemistry, Japan
- 巻号年月日等（掲載誌）
- 70(2)=823:2012.2
- 掲載巻
- 70
- 掲載号
- 2
- 掲載通号
- 823
- 掲載ページ
- 113-130
- 掲載年月日（W3CDTF）
- 2012-02
- ISSN（掲載誌）
- 0037-9980
- ISSN-L（掲載誌）
- 0037-9980
- 出版事項（掲載誌）
- 東京 : 有機合成化学協会
- 出版地（国名コード）
- JP
- 本文の言語コード
- jpn
- 件名標目
- NDLC
- 対象利用者
- 一般
- 所蔵機関
- 国立国会図書館
- 請求記号
- Z17-256
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- 書誌ID（NDLBibID）
- 023517134
- 整理区分コード
- 632
- 要約等
- Immunostimulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthesis of partial structures and analogues of lipopolysaccharide and its bioactive principle ‘lipid A’ contributed the elucidation of mode of action, i.e., interaction of lipopolysaccharide with its receptor ‘TLR4/MD-2 complex’. Immunomodulation by parasitic bacteria ‘<i>Helicobacter pylori</i>’ was elucidated by using synthetic lipopolysaccharide partial structures. Intracellular peptidoglycan receptors, ‘Nod1’ and ‘Nod2’, and their ligand structures were identified by using synthetic peptidoglycan partial structures. New Nod1 ligands were identified from the bacterial supernatant. <i>In vivo</i> function of Nod1 was studied by using synthetic ligands found from small library of Nod1 ligands.
- DOI
- 10.5059/yukigoseikyokaishi.70.113
- オンライン閲覧公開範囲
- インターネット公開
- 連携機関・データベース
- 科学技術振興機構 : J-STAGE
- 要約等
- Immunostimulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthesis of partial structures and analogues of lipopolysaccharide and its bioactive principle ‘lipid A’ contributed the elucidation of mode of action, i.e., interaction of lipopolysaccharide with its receptor ‘TLR4/MD-2 complex’. Immunomodulation by parasitic bacteria ‘<i>Helicobacter pylori</i>’ was elucidated by using synthetic lipopolysaccharide partial structures. Intracellular peptidoglycan receptors, ‘Nod1’ and ‘Nod2’, and their ligand structures were identified by using synthetic peptidoglycan partial structures. New Nod1 ligands were identified from the bacterial supernatant. <i>In vivo</i> function of Nod1 was studied by using synthetic ligands found from small library of Nod1 ligands.
- DOI
- 10.5059/yukigoseikyokaishi.70.113
- 参照
- Chemically Synthesized TLR4 Ligands, Their Immunological Functions, and Potential as Vaccine AdjuvantLipid A-Mediated Bacterial–Host Chemical Ecology: Synthetic Research of Bacterial Lipid As and Their Development as Adjuvants進歩し続けるグリコシル化反応とオリゴ糖合成中分子戦略と複合化による高次免疫制御分子の創製寄生・共生菌リピドAを起点としたアジュバント開発リピドAの化学合成が拓くワクチンアジュバント開発
- 参照
- Recent advances in carbohydrate-based vaccinesSynthetic approach to bacterial lipopolysaccharide, preparation of trisaccharide part structures containing KDO and 1-dephospho lipid AThe structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complexBiological activity of synthetic heptaacyl lipid A representing a component of <i>Salmonella minnesota</i> R595 lipid AReinvestigation of the C5-acetamide sialic acid donor for α-selective sialylation: practical procedure under microfluidic conditionsAn efficient phosphorylation method using a new phosphitylating agent, 2-diethylamino-1,3,2-benzodioxaphosphepaneDifferential Release and Distribution of Nod1 and Nod2 Immunostimulatory Molecules among Bacterial Species and EnvironmentsNod‐like proteins in inflammation and diseaseBioorthogonal chemical reporter methodology for visualization, isolation and analysis of glycoconjugatesConformational Study of a Tetraacyl Biosynthetic Precursor of Lipid A by NMRStructures, Synthesis, and Human Nod1 Stimulation of Immunostimulatory Bacterial Peptidoglycan Fragments in the EnvironmentToll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharideDivergent synthesis and biological activities of lipid A analogues of shorter acyl chainsDifferential Activation of Human TLR4 by <i>Escherichia coli</i> and <i>Shigella flexneri</i> 2a Lipopolysaccharide: Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on SignalingAS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive ImmunityFirst Total Synthesis of the Re-Type LipopolysaccharideCutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene ProductNew Efficient Synthesis of a Biosynthetic Precursor of Lipid AEndotoxic and immunobiological activities of a chemically synthesized lipid A of<i>Helicobacter pylori</i>strain 206â1Synthetic study of peptidoglycan partial structures. Synthesis of tetrasaccharide and octasaccharide fragmentsSynthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activitiesDefective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> GeneSelf and Nonself Recognition with Bacterial and Animal Glycans, Surveys by Synthetic ChemistryLipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2Preparation of novel pyranosyl fluorides of 3-deoxy-D- -2-octulosonic acid (KDO) feasible for synthesis of KDO α-glycosidesRenewed Synthetic Approach to Gangliosides Exploiting Versatile and Powerful Synthetic UnitsToll-Like ReceptorsGlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectivesSynthesis and purification by HPLC of des-O-acyl partial structures of Escherichia coli Re lipopolysaccharideE5531, a Pure Endotoxin Antagonist of High PotencyLipid A-like molecules that antagonize the effects of endotoxins on human monocytes.Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial PeptidoglycanStructural studies on the non‐toxic lipid A from <i>Rhodopseudomonas sphaeroides</i> ATCC 17023Synthesis of Helicobacter pylori lipid A and its analogue using p-(trifluoromethyl)benzyl protecting groupRegioselective Reductive Opening of 4,6-<i>O</i>-Benzylidene Acetals of Glucose or Glucosamine Derivatives by BH<sub>3</sub>⋅Me<sub>2</sub>NH - BF<sub>3</sub>⋅OEt<sub>2</sub>Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structuresSynthesis of a Sialic Acid Containing Complex‐Type <i>N</i>‐Glycan on a Solid SupportSynthesis and biological function of bacterial endotoxinA Novel Class of Endotoxin Receptor Agonists with Simplified Structure, Toll-Like Receptor 4-Dependent Immunostimulatory Action, and Adjuvant ActivityCrystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist EritoranAntagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogueSynthesis of Diaminopimelic Acid Containing Peptidoglycan Fragments and Tracheal Cytotoxin (TCT) and Investigation of Their Biological FunctionsEritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studiesEndotoxic properties of synthetic pentaacyl lipid A precursor Ib and a structural isomerStructural Polymorphism and Endotoxic Activity of Synthetic Phospholipid-like AmphiphilesHuman Peptidoglycan Recognition Protein-L Is an N-Acetylmuramoyl-L-alanine AmidaseHost Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signalingNod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) DetectionNew synthesis and conformational analysis of lipid A: biological activity and supramolecular assemblyNod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivoCharacterization of Natural Human Nucleotide-binding Oligomerization Domain Protein 1 (Nod1) Ligands from Bacterial Culture Supernatant for Elucidation of Immune Modulators in the EnvironmentNLR, the nucleotide-binding domain leucine-rich repeat containing gene familyHighly Efficient α‐Sialylation by Virtue of Fixed Dipole Effects of<i>N</i>‐Phthalyl Group: Application to Continuous Flow Synthesis of α(2‐3)‐and α(2‐6)‐Neu5Ac‐Gal Motifs by MicroreactorA Role of Lipophilic Peptidoglycan-related Molecules in Induction of Nod1-mediated Immune ResponsesEfficient Sialylation with Phenyltrifluoroacetimidates as Leaving GroupsSynthesis and Biological Activities of Biscarboxymethyl Lipid A AnaloguesThe role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsSynthesis of peptidoglycan fragments and evaluation of their biological activityMD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivityHuman peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunityAn essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acidVirulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide responseAutophagic control of listeria through intracellular innate immune recognition in drosophilaCD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.4‐(Dimethylamino)pyridine <i>N</i>‐oxide (DMAPO): An Effective Nucleophilic Catalyst in the Peptide Coupling Reaction with 2‐Methyl‐6‐nitrobenzoic AnhydrideStructural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogsNMR conformational analysis of biosynthetic precursor-type lipid A: monomolecular state and supramolecular assemblyChemical approaches toward understanding glycan-mediated protein quality controlA Synthetic Peptidoglycan Fragment as a Competitive Inhibitor of the Melanization CascadeSynthesis of 13C-Labeled Biosynthetic Precursor of Lipid A and Its Analogue with Shorter Acyl ChainsSynthesis and Biological Activities of Analogs of a Lipid A Biosynthetic Precursor: 1-O-Phosphonooxyethyl-4'-O-phosphono-disaccharides with (R)-3-Hydroxytetradecanoyl or Tetradecanoyl Groups at Positions 2, 3, 2' and 3'.糖質化学の裏庭に漫歩してSynthesis and biological activities of lipid A analogs possessing β-glycosidic linkage at 1-positionA Divergent Synthesis of Lipid A and Its Chemically Stable Unnatural Analogues.Synthesis of [3H]-Labeled Bioactive Lipid A Analogs and Their Use for Detection of Lipid A-Binding Proteins on Murine Macrophages.Synthesis of <i>Rubrivivax gelatinosus</i> Lipid A and Analogues for Investigation of the Structural Basis for Immunostimulating and Inhibitory ActivitiesKey structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studiesSynthesis and antitumor activity of lipid A analogs having a phosphonooxyethyl group with .ALPHA.- or .BETA.-configuration at position 1.Ｒｅ型リポ多糖の全合成Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clusteringToll-like receptor signallingCrystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Japan Link Center雑誌記事索引データベースCrossrefCiNii Articles科学研究費助成事業データベース科学研究費助成事業データベース科学研究費助成事業データベースCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossref
- 書誌ID（NDLBibID）
- 023517134
- NII論文ID
- 10030481197