細菌由来複合糖質の合成と自然免疫研究
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- Material Type
- 記事
- Title
- Author/Editor
- 深瀬 浩一藤本 ゆかり下山 敦史 他
- Alternative Title
- Synthesis of Bacterial Glycoconjugates and Their Bio-functional Studies in Innate Immunity
- Periodical title
- 有機合成化学協会誌 = Journal of synthetic organic chemistry, Japan
- No. or year of volume/issue
- 70(2)=823:2012.2
- Volume
- 70
- Issue
- 2
- Sequential issue number
- 823
- Pages
- 113-130
- Publication date of volume/issue (W3CDTF)
- 2012-02
- ISSN (Periodical Title)
- 0037-9980
- ISSN-L (Periodical Title)
- 0037-9980
- Publication (Periodical Title)
- 東京 : 有機合成化学協会
- Place of Publication (Country Code)
- JP
- Text Language Code
- jpn
- Subject Heading
- NDLC
- Target Audience
- 一般
- Holding library
- 国立国会図書館
- Call No.
- Z17-256
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- Bibliographic ID (NDL)
- 023517134
- Bibliographic Record Category (NDL)
- 632
- Summary, etc.
- Immunostimulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthesis of partial structures and analogues of lipopolysaccharide and its bioactive principle ‘lipid A’ contributed the elucidation of mode of action, i.e., interaction of lipopolysaccharide with its receptor ‘TLR4/MD-2 complex’. Immunomodulation by parasitic bacteria ‘<i>Helicobacter pylori</i>’ was elucidated by using synthetic lipopolysaccharide partial structures. Intracellular peptidoglycan receptors, ‘Nod1’ and ‘Nod2’, and their ligand structures were identified by using synthetic peptidoglycan partial structures. New Nod1 ligands were identified from the bacterial supernatant. <i>In vivo</i> function of Nod1 was studied by using synthetic ligands found from small library of Nod1 ligands.
- DOI
- 10.5059/yukigoseikyokaishi.70.113
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- Immunostimulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthesis of partial structures and analogues of lipopolysaccharide and its bioactive principle ‘lipid A’ contributed the elucidation of mode of action, i.e., interaction of lipopolysaccharide with its receptor ‘TLR4/MD-2 complex’. Immunomodulation by parasitic bacteria ‘<i>Helicobacter pylori</i>’ was elucidated by using synthetic lipopolysaccharide partial structures. Intracellular peptidoglycan receptors, ‘Nod1’ and ‘Nod2’, and their ligand structures were identified by using synthetic peptidoglycan partial structures. New Nod1 ligands were identified from the bacterial supernatant. <i>In vivo</i> function of Nod1 was studied by using synthetic ligands found from small library of Nod1 ligands.
- DOI
- 10.5059/yukigoseikyokaishi.70.113
- Related Material (URI)
- Is Referenced By
- Chemically Synthesized TLR4 Ligands, Their Immunological Functions, and Potential as Vaccine AdjuvantLipid A-Mediated Bacterial–Host Chemical Ecology: Synthetic Research of Bacterial Lipid As and Their Development as Adjuvants進歩し続けるグリコシル化反応とオリゴ糖合成中分子戦略と複合化による高次免疫制御分子の創製寄生・共生菌リピドAを起点としたアジュバント開発リピドAの化学合成が拓くワクチンアジュバント開発
- References
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Synthesis of tetrasaccharide and octasaccharide fragmentsSynthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activitiesDefective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> GeneSelf and Nonself Recognition with Bacterial and Animal Glycans, Surveys by Synthetic ChemistryLipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2Preparation of novel pyranosyl fluorides of 3-deoxy-D- -2-octulosonic acid (KDO) feasible for synthesis of KDO α-glycosidesRenewed Synthetic Approach to Gangliosides Exploiting Versatile and Powerful Synthetic UnitsToll-Like ReceptorsGlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectivesSynthesis and purification by HPLC of des-O-acyl partial structures of Escherichia coli Re lipopolysaccharideE5531, a Pure Endotoxin Antagonist of High PotencyLipid A-like molecules that antagonize the effects of endotoxins on human monocytes.Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial PeptidoglycanStructural studies on the non‐toxic lipid A from <i>Rhodopseudomonas sphaeroides</i> ATCC 17023Synthesis of Helicobacter pylori lipid A and its analogue using p-(trifluoromethyl)benzyl protecting groupRegioselective Reductive Opening of 4,6-<i>O</i>-Benzylidene Acetals of Glucose or Glucosamine Derivatives by BH<sub>3</sub>⋅Me<sub>2</sub>NH - BF<sub>3</sub>⋅OEt<sub>2</sub>Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structuresSynthesis of a Sialic Acid Containing Complex‐Type <i>N</i>‐Glycan on a Solid SupportSynthesis and biological function of bacterial endotoxinA Novel Class of Endotoxin Receptor Agonists with Simplified Structure, Toll-Like Receptor 4-Dependent Immunostimulatory Action, and Adjuvant ActivityCrystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist EritoranAntagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogueSynthesis of Diaminopimelic Acid Containing Peptidoglycan Fragments and Tracheal Cytotoxin (TCT) and Investigation of Their Biological FunctionsEritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studiesEndotoxic properties of synthetic pentaacyl lipid A precursor Ib and a structural isomerStructural Polymorphism and Endotoxic Activity of Synthetic Phospholipid-like AmphiphilesHuman Peptidoglycan Recognition Protein-L Is an N-Acetylmuramoyl-L-alanine AmidaseHost Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signalingNod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) DetectionNew synthesis and conformational analysis of lipid A: biological activity and supramolecular assemblyNod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivoCharacterization of Natural Human Nucleotide-binding Oligomerization Domain Protein 1 (Nod1) Ligands from Bacterial Culture Supernatant for Elucidation of Immune Modulators in the EnvironmentNLR, the nucleotide-binding domain leucine-rich repeat containing gene familyHighly Efficient α‐Sialylation by Virtue of Fixed Dipole Effects of<i>N</i>‐Phthalyl Group: Application to Continuous Flow Synthesis of α(2‐3)‐and α(2‐6)‐Neu5Ac‐Gal Motifs by MicroreactorA Role of Lipophilic Peptidoglycan-related Molecules in Induction of Nod1-mediated Immune ResponsesEfficient Sialylation with Phenyltrifluoroacetimidates as Leaving GroupsSynthesis and Biological Activities of Biscarboxymethyl Lipid A AnaloguesThe role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsSynthesis of peptidoglycan fragments and evaluation of their biological activityMD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivityHuman peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunityAn essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acidVirulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide responseAutophagic control of listeria through intracellular innate immune recognition in drosophilaCD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.4‐(Dimethylamino)pyridine <i>N</i>‐oxide (DMAPO): An Effective Nucleophilic Catalyst in the Peptide Coupling Reaction with 2‐Methyl‐6‐nitrobenzoic AnhydrideStructural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogsNMR conformational analysis of biosynthetic precursor-type lipid A: monomolecular state and supramolecular assemblyChemical approaches toward understanding glycan-mediated protein quality controlA Synthetic Peptidoglycan Fragment as a Competitive Inhibitor of the Melanization CascadeSynthesis of 13C-Labeled Biosynthetic Precursor of Lipid A and Its Analogue with Shorter Acyl ChainsSynthesis and Biological Activities of Analogs of a Lipid A Biosynthetic Precursor: 1-O-Phosphonooxyethyl-4'-O-phosphono-disaccharides with (R)-3-Hydroxytetradecanoyl or Tetradecanoyl Groups at Positions 2, 3, 2' and 3'.糖質化学の裏庭に漫歩してSynthesis and biological activities of lipid A analogs possessing β-glycosidic linkage at 1-positionA Divergent Synthesis of Lipid A and Its Chemically Stable Unnatural Analogues.Synthesis of [3H]-Labeled Bioactive Lipid A Analogs and Their Use for Detection of Lipid A-Binding Proteins on Murine Macrophages.Synthesis of <i>Rubrivivax gelatinosus</i> Lipid A and Analogues for Investigation of the Structural Basis for Immunostimulating and Inhibitory ActivitiesKey structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studiesSynthesis and antitumor activity of lipid A analogs having a phosphonooxyethyl group with .ALPHA.- or .BETA.-configuration at position 1.Ｒｅ型リポ多糖の全合成Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clusteringToll-like receptor signallingCrystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベースCrossrefCiNii Articles科学研究費助成事業データベース科学研究費助成事業データベース科学研究費助成事業データベースCrossrefCrossrefCrossrefCrossrefCrossrefCrossrefCrossref
- Bibliographic ID (NDL)
- 023517134
- NAID
- 10030481197