タイトル(掲載誌)JOURNAL OF MAGNETIC RESONANCE IMAGING
一般注記Purpose: To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue. Materials and Methods: Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion-weighted (DW) echo-planar imaging (b value=0, 500 s/mm^2) was employed to calculate ADC. ADC values of cancer and non-cancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results. Results: Mean (±standard deviation) ADC value was significantly lower for tumor (1.27±0.52 ×10^<-3> mm^2/s) than for non-cancerous tissue (1.90±0.41×10^<-3> mm^2/s, P<0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis and mucin in each case. Regarding the density of fibrosis in cancer, 3 cases were classified to the loose fibrosis group, and the remaining 7 cases were classified to the dense fibrosis group. Mean ADC value was significantly higher in the loose fibrosis group (1.88±0.39×10^<-3> mm^2/s) than in the dense fibrosis group (1.01±0.29×10^<-3> mm^2/s, P<0.05). In quantitative analysis, ADC correlated well with proportion of collagenous fibers (r=-0.87, P<0.05). Conclusion: Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer.
一次資料へのリンクURLhttps://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19863&item_no=1&attribute_id=22&file_no=1
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース(IRDB)(機関リポジトリ)