Apparent Diffusion Coefficient in Pancreatic Cancer: Characterization and Histopathological Correlations

Material type: 文書・図像類

Author: MURAOKA, Noriakiほか

Publisher: JOHN WILEY & SONS INC

Publication date: 2008-06

Material Format: Digital

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Note (General)：: Purpose: To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue. Materials and Methods: Subjects c...

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Material Type: 文書・図像類
Title: Apparent Diffusion Coefficient in Pancreatic Cancer: Characterization and Histopathological Correlations
Author/Editor: MURAOKA, Noriaki
UEMATSU, Hidemasa
KIMURA, Hirohiko
IMAMURA, Yoshiaki
FUJIWARA, Yasuhiro
MURAKAMI, Makoto
YAMAGUCHI, Akio
ITOH, Harumi
Author Heading: MURAOKA, Noriaki
UEMATSU, Hidemasa
KIMURA, Hirohiko
IMAMURA, Yoshiaki
FUJIWARA, Yasuhiro
MURAKAMI, Makoto
YAMAGUCHI, Akio
ITOH, Harumi
Publication, Distribution, etc.: JOHN WILEY & SONS INC
Publication Date: 2008-06
Publication Date (W3CDTF): 2008-06
Periodical title: JOURNAL OF MAGNETIC RESONANCE IMAGING
No. or year of volume/issue: 27 6
Volume: 27
Issue: 6
Pages: 1302-1308
ISSN (Periodical Title): ISSN : 1053-1807
Text Language Code: eng
Subject Heading: pancreatic cancer
diffusion-weighted imaging
apparent diffusion coefficient
histopathological correlations
Target Audience: 一般
Note (General): Purpose: To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue. Materials and Methods: Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion-weighted (DW) echo-planar imaging (b value=0, 500 s/mm^2) was employed to calculate ADC. ADC values of cancer and non-cancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results. Results: Mean (±standard deviation) ADC value was significantly lower for tumor (1.27±0.52 ×10^<-3> mm^2/s) than for non-cancerous tissue (1.90±0.41×10^<-3> mm^2/s, P<0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis and mucin in each case. Regarding the density of fibrosis in cancer, 3 cases were classified to the loose fibrosis group, and the remaining 7 cases were classified to the dense fibrosis group. Mean ADC value was significantly higher in the loose fibrosis group (1.88±0.39×10^<-3> mm^2/s) than in the dense fibrosis group (1.01±0.29×10^<-3> mm^2/s, P<0.05). In quantitative analysis, ADC correlated well with proportion of collagenous fibers (r=-0.87, P<0.05). Conclusion: Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer.
Source: https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19863&item_no=1&attribute_id=22&file_no=1
https://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19863&item_no=1&attribute_id=22&file_no=1
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ