High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy.

• 資料種別: 文書・図像類
• タイトル: High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy.
• 著者・編者: YONEDA, M; FUJII, A; ITO, A; YOKOYAMA, H; NAKAGAWA, H; KURIYAMA, M
• 著者標目: YONEDA, M; FUJII, A; ITO, A; YOKOYAMA, H; NAKAGAWA, H; KURIYAMA, M
• 出版事項: Elsevier
• 出版年月日等: 2007-04
• 出版年（W3CDTF）: 2007-04
• タイトル（掲載誌）: Journal of neuroimmunology
• 巻号年月日等（掲載誌）: 185 1-2
• 掲載巻: 185
• 掲載号: 1-2
• 掲載ページ: 195-200
• 本文の言語コード: eng
• 件名標目: Hashimoto's encephalopathy; Autoantibodies; NAE; Clinical features
• 対象利用者: 一般
• 一般注記: Recently, we discovered autoantibodies against the amino (NH(2))-terminal of alpha-enolase (NAE) in patients with Hashimoto's encephalopathy (HE) (83.3%; 5/6) [Fujii, A., Yoneda, M., Ito, T., Yamamura, O., Satomi, S., Higa, H., Kimura, M., Suzuki, M., Yamashita, M., Yuasa, T., Suzuki, H., Kuriyama, M., 2005. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's encephalopathy. J. Neuroimmunol. 162, 130-136]. We further investigated the anti-NAE autoantibodies in 25 patients who fit the diagnostic criteria for HE, based on the presence of anti-thyroid antibodies and responsiveness to immunotherapy. In this study, we demonstrated a high prevalence (68%, 17 of 25) and high specificity of anti-NAE autoantibodies in patients with HE, and clarified the clinical features of HE. This result demonstrated that anti-NAE autoantibodies, in addition to anti-thyroid autoantibodies, are emphasized as useful serological diagnostic markers of HE.
• オンライン閲覧公開範囲: 限定公開
• 関連情報（DOI）: 10.1016/j.jneuroim.2007.01.018
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 福井大学 : 福井大学学術機関リポジトリ