High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy.

Material type: 文書・図像類

Author: YONEDA, Mほか

Publisher: Elsevier

Publication date: 2007-04

Material Format: Digital

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Note (General)：: Recently, we discovered autoantibodies against the amino (NH(2))-terminal of alpha-enolase (NAE) in patients with Hashimoto's encephalopathy (HE) (83....

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Material Type: 文書・図像類
Title: High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy.
Author/Editor: YONEDA, M
FUJII, A
ITO, A
YOKOYAMA, H
NAKAGAWA, H
KURIYAMA, M
Author Heading: YONEDA, M
FUJII, A
ITO, A
YOKOYAMA, H
NAKAGAWA, H
KURIYAMA, M
Publication, Distribution, etc.: Elsevier
Publication Date: 2007-04
Publication Date (W3CDTF): 2007-04
Periodical title: Journal of neuroimmunology
No. or year of volume/issue: 185 1-2
Volume: 185
Issue: 1-2
Pages: 195-200
Text Language Code: eng
Subject Heading: Hashimoto's encephalopathy
Autoantibodies
NAE
Clinical features
Target Audience: 一般
Note (General): Recently, we discovered autoantibodies against the amino (NH(2))-terminal of alpha-enolase (NAE) in patients with Hashimoto's encephalopathy (HE) (83.3%; 5/6) [Fujii, A., Yoneda, M., Ito, T., Yamamura, O., Satomi, S., Higa, H., Kimura, M., Suzuki, M., Yamashita, M., Yuasa, T., Suzuki, H., Kuriyama, M., 2005. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's encephalopathy. J. Neuroimmunol. 162, 130-136]. We further investigated the anti-NAE autoantibodies in 25 patients who fit the diagnostic criteria for HE, based on the presence of anti-thyroid antibodies and responsiveness to immunotherapy. In this study, we demonstrated a high prevalence (68%, 17 of 25) and high specificity of anti-NAE autoantibodies in patients with HE, and clarified the clinical features of HE. This result demonstrated that anti-NAE autoantibodies, in addition to anti-thyroid autoantibodies, are emphasized as useful serological diagnostic markers of HE.
Access Restrictions: 限定公開
Related Material (DOI): 10.1016/j.jneuroim.2007.01.018
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 福井大学 : 福井大学学術機関リポジトリ