Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures

• 資料種別: 博士論文
• タイトル: Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures
• 著者・編者: Kakuta, Nami; Tsutsumi, Yasuo M.; Horikawa, Yousuke T.; Kawano, Hiroaki; Kinoshita, Michiko; Tanaka, Katsuya; Oshita, Shuzo
• 著者標目: Kakuta, Nami; Tsutsumi, Yasuo M.; Horikawa, Yousuke T.; Kawano, Hiroaki; Kinoshita, Michiko; Tanaka, Katsuya; Oshita, Shuzo
• 出版年月日等: 2011-08
• 出版年（W3CDTF）: 2011-08
• 並列タイトル等: 婦人科腹腔鏡下手術でニューロキニン1受容体拮抗薬アプレピタントは術後の嘔気・嘔吐を減少させる; NK-1 receptor antagonism decreases PONV
• タイトル（掲載誌）: The journal of medical investigation : JMI
• 巻号年月日等（掲載誌）: 58 3-4
• 掲載巻: 58
• 掲載号: 3-4
• 掲載ページ: 246-251
• ISSN（掲載誌）: ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2015-04-23
• 報告番号: 甲第2854号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: neurokinin-1 receptor; post-operative nausea and vomiting; aprepitant; laparoscopic gynecological surgery
• 対象利用者: 一般
• 一般注記: Purpose : Post-operative nausea and vomiting (PONV) remains the most frequently reported patient complaint after anesthesia. Aprepitant is the first neurokinin-1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery. Methods : Sixty four patients receiving general anesthesia for laparoscopic gynecological surgery were randomly assigned to either receive a preoperative dose of 80mg aprepitant or no drug. Efficacy was assessed in 2 and 24 hours after surgery. Primary and secondary endpoints were analyzed for the time intervals 0-2 hours (acute phase) and 2-24 hours (delayed phase). Vomiting, nausea, use of rescue anti-emetic, and visual analog scale (VAS) were assessed. Nausea was assessed on a 4-point scale, from 0 to 3. Results : Sixty patients participated in the study. At acute phase, PONV was present in both control and NK1 group and were 63% and 43% respectively. The severity of nausea was much less in the NK1 group. PONV prevalence at delayed phase was present in control but absent in NK1 group 27% vs. 0%, respectively. The amount of pain medication used by patients in the NK1 group was significantly less for diclofenac and pentazocine suggesting increase pain tolerance. Conclusions : Neurokinin-1 receptor antagonism effectively lowered PONV increased pain tolerance, and expedited recovery in patients undergoing laparoscopic gynecological surgery.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.58.246
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/8/83838/20190807105805411567/LID201506051008.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/8/83838/20190807105805733711/LID201506051009.pdf fulltext