Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures

• Material Type: 博士論文
• Title: Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures
• Author/Editor: Kakuta, Nami; Tsutsumi, Yasuo M.; Horikawa, Yousuke T.; Kawano, Hiroaki; Kinoshita, Michiko; Tanaka, Katsuya; Oshita, Shuzo
• Author Heading: Kakuta, Nami; Tsutsumi, Yasuo M.; Horikawa, Yousuke T.; Kawano, Hiroaki; Kinoshita, Michiko; Tanaka, Katsuya; Oshita, Shuzo
• Publication Date: 2011-08
• Publication Date (W3CDTF): 2011-08
• Alternative Title: 婦人科腹腔鏡下手術でニューロキニン1受容体拮抗薬アプレピタントは術後の嘔気・嘔吐を減少させる; NK-1 receptor antagonism decreases PONV
• Periodical title: The journal of medical investigation : JMI
• No. or year of volume/issue: 58 3-4
• Volume: 58
• Issue: 3-4
• Pages: 246-251
• ISSN (Periodical Title): ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2015-04-23
• Dissertation Number: 甲第2854号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: neurokinin-1 receptor; post-operative nausea and vomiting; aprepitant; laparoscopic gynecological surgery
• Target Audience: 一般
• Note (General): Purpose : Post-operative nausea and vomiting (PONV) remains the most frequently reported patient complaint after anesthesia. Aprepitant is the first neurokinin-1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery. Methods : Sixty four patients receiving general anesthesia for laparoscopic gynecological surgery were randomly assigned to either receive a preoperative dose of 80mg aprepitant or no drug. Efficacy was assessed in 2 and 24 hours after surgery. Primary and secondary endpoints were analyzed for the time intervals 0-2 hours (acute phase) and 2-24 hours (delayed phase). Vomiting, nausea, use of rescue anti-emetic, and visual analog scale (VAS) were assessed. Nausea was assessed on a 4-point scale, from 0 to 3. Results : Sixty patients participated in the study. At acute phase, PONV was present in both control and NK1 group and were 63% and 43% respectively. The severity of nausea was much less in the NK1 group. PONV prevalence at delayed phase was present in control but absent in NK1 group 27% vs. 0%, respectively. The amount of pain medication used by patients in the NK1 group was significantly less for diclofenac and pentazocine suggesting increase pain tolerance. Conclusions : Neurokinin-1 receptor antagonism effectively lowered PONV increased pain tolerance, and expedited recovery in patients undergoing laparoscopic gynecological surgery.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.58.246
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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