Serum carboxy-terminal telopeptide of type Ⅰ collagen (ICTP) as a surrogate marker for vulnerable plaques in atherosclerotic patients : a pilot study

• 資料種別: 博士論文
• タイトル: Serum carboxy-terminal telopeptide of type Ⅰ collagen (ICTP) as a surrogate marker for vulnerable plaques in atherosclerotic patients : a pilot study
• 著者・編者: Kato, Shuji; Endo, Itsuro; Fujimura, Mitsunori; Kuriwaka-Kido, Rika; Fujinaka, Yuichi; Aihara, Ken-ichi; Iwase, Takashi; Inoue, Daisuke; Akaike, Masashi; Abe, Masahiro; Matsumoto, Toshio
• 著者標目: Kato, Shuji; Endo, Itsuro; Fujimura, Mitsunori; Kuriwaka-Kido, Rika; Fujinaka, Yuichi; Aihara, Ken-ichi; Iwase, Takashi; Inoue, Daisuke; Akaike, Masashi; Abe, Masahiro; Matsumoto, Toshio
• 出版事項: Elsevier
• 出版年月日等: 2013-04-06
• 出版年（W3CDTF）: 2013-04-06
• 並列タイトル等: 動脈硬化患者における不安定プラークの予測因子としての血清ICTP; ICTP and vulnerable plaque
• タイトル（掲載誌）: Atherosclerosis
• 巻号年月日等（掲載誌）: 229 1
• 掲載巻: 229
• 掲載号: 1
• 掲載ページ: 182-185
• ISSN（掲載誌）: ISSN : 0021-9150
• 授与機関名: 徳島大学
• 授与年月日: 2013-09-26
• 報告番号: 甲第2649号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: ICTP; vulnerable plaque; necrotic core; matrix metalloproteinase; type I collagen
• 対象利用者: 一般
• 一般注記: Evaluation of atherosclerotic plaques depends on invasive intravascular ultrasonography (IVUS). Carboxy-terminal telopeptide of type I collagen (ICTP) is produced by matrix metalloproteinase (MMP)-dependent digestion of type I collagen. Because vulnerable plaques are rich in type I collagen and MMPs from macrophages, we examined the association between serum ICTP and coronary plaques in patients with coronary disease. We recruited 46 men and 17 women without renal failure or bone diseases affecting serum ICTP, who underwent coronary IVUS. Serum ICTP levels were higher in patients with coronary plaques containing more than 10% necrotic core area than in patients with less than 10% necrotic core area. A positive correlation was found between serum ICTP and necrotic core area. Only serum ICTP was positively correlated with necrotic core area by multivariate analysis (p<0.05). These results suggest that serum ICTP can be used as a non-invasive marker of vulnerable plaques in atherosclerotic patients.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.atherosclerosis.2013.03.030
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/10/105936/20170929150341462696/LID201311261001.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/10/105936/20170929150341776353/LID201405271001.pdf fulltext