Serum carboxy-terminal telopeptide of type Ⅰ collagen (ICTP) as a surrogate marker for vulnerable plaques in atherosclerotic patients : a pilot study

• Material Type: 博士論文
• Title: Serum carboxy-terminal telopeptide of type Ⅰ collagen (ICTP) as a surrogate marker for vulnerable plaques in atherosclerotic patients : a pilot study
• Author/Editor: Kato, Shuji; Endo, Itsuro; Fujimura, Mitsunori; Kuriwaka-Kido, Rika; Fujinaka, Yuichi; Aihara, Ken-ichi; Iwase, Takashi; Inoue, Daisuke; Akaike, Masashi; Abe, Masahiro; Matsumoto, Toshio
• Author Heading: Kato, Shuji; Endo, Itsuro; Fujimura, Mitsunori; Kuriwaka-Kido, Rika; Fujinaka, Yuichi; Aihara, Ken-ichi; Iwase, Takashi; Inoue, Daisuke; Akaike, Masashi; Abe, Masahiro; Matsumoto, Toshio
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2013-04-06
• Publication Date (W3CDTF): 2013-04-06
• Alternative Title: 動脈硬化患者における不安定プラークの予測因子としての血清ICTP; ICTP and vulnerable plaque
• Periodical title: Atherosclerosis
• No. or year of volume/issue: 229 1
• Volume: 229
• Issue: 1
• Pages: 182-185
• ISSN (Periodical Title): ISSN : 0021-9150
• Degree grantor/type: 徳島大学
• Date Granted: 2013-09-26
• Dissertation Number: 甲第2649号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: ICTP; vulnerable plaque; necrotic core; matrix metalloproteinase; type I collagen
• Target Audience: 一般
• Note (General): Evaluation of atherosclerotic plaques depends on invasive intravascular ultrasonography (IVUS). Carboxy-terminal telopeptide of type I collagen (ICTP) is produced by matrix metalloproteinase (MMP)-dependent digestion of type I collagen. Because vulnerable plaques are rich in type I collagen and MMPs from macrophages, we examined the association between serum ICTP and coronary plaques in patients with coronary disease. We recruited 46 men and 17 women without renal failure or bone diseases affecting serum ICTP, who underwent coronary IVUS. Serum ICTP levels were higher in patients with coronary plaques containing more than 10% necrotic core area than in patients with less than 10% necrotic core area. A positive correlation was found between serum ICTP and necrotic core area. Only serum ICTP was positively correlated with necrotic core area by multivariate analysis (p<0.05). These results suggest that serum ICTP can be used as a non-invasive marker of vulnerable plaques in atherosclerotic patients.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.atherosclerosis.2013.03.030
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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