Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice

• 資料種別: 博士論文
• タイトル: Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice
• 著者・編者: Nakahashi, Otoki; Yamamoto, Hironori; Tanaka, Sarasa; Kozai, Mina; Takei, Yuichiro; Masuda, Masashi; Kaneko, Ichiro; Taketani, Yutaka; Iwano, Masayuki; Miyamoto, Ken-ichi; Takeda, Eiji
• 著者標目: Nakahashi, Otoki; Yamamoto, Hironori; Tanaka, Sarasa; Kozai, Mina; Takei, Yuichiro; Masuda, Masashi; Kaneko, Ichiro; Taketani, Yutaka; Iwano, Masayuki; Miyamoto, Ken-ichi; Takeda, Eiji
• 出版事項: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
• 出版年月日等: 2014-03-01
• 出版年（W3CDTF）: 2014-03-01
• 並列タイトル等: マウスにおいて短期間の食餌性リン制限は回腸fibroblast growth factor 15遺伝子発現量を増加させる
• タイトル（掲載誌）: Journal of Clinical Biochemistry and Nutrition
• 巻号年月日等（掲載誌）: 54 2
• 掲載巻: 54
• 掲載号: 2
• 掲載ページ: 102-108
• ISSN（掲載誌）: ISSN : 1880-5086; ISSN : 0912-0009
• 授与機関名: 徳島大学
• 授与年月日: 2014-03-24
• 報告番号: 甲第2678号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: fibroblast growth factor 15; gene regulation analysis; inorganic phosphate; 1,25-dihydroxyvitamin D; mice
• 対象利用者: 一般
• 一般注記: Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy. It has been reported that dietary Pi regulates circulating FGF23. In this study, the short-term effects of dietary Pi restriction on the expression of FGF19 subfamily members in mice were analyzed. An initial analysis confirmed plasma FGF23 levels positively correlated with the amount of dietary Pi. On the other hand, ileal Fgf15 gene expression, but not hepatic Fgf21 gene expression, was up-regulated by dietary Pi restriction. In addition, we observed the increase of plasma 1,25-dihydroxyvitamin D [1,25(OH)2D] levels by dietary Pi restriction, and the up-regulation of ileal Fgf15 mRNA expression by 1,25(OH)2D3 and vitamin D receptor (VDR). Importantly, dietary Pi restriction-induced Fgf15 gene expression was prevented in VDR-knockout mice. Furthermore, diurnal variations of plasma triglyceride concentrations and hepatic mRNA expression of the bile acid synthesis enzyme Cyp7a1 as one of Fgf15 negative target genes was influenced by dietary Pi restriction. These results suggest that dietary Pi restriction up-regulates ileal Fgf15 gene expression through 1,25(OH)2D3 and VDR, and may affect hepatic bile acid homeostasis.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2014 Society for Free Radical Research Japan
• 関連情報（DOI）: 10.3164/jcbn.13-109
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/10/106159/2017092914523228467/LID201405161005.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/10/106159/20200410153644159438/k2678_fulltext.pdf fulltext