Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice

• Material Type: 博士論文
• Title: Short-term dietary phosphate restriction up-regulates ileal fibroblast growth factor 15 gene expression in mice
• Author/Editor: Nakahashi, Otoki; Yamamoto, Hironori; Tanaka, Sarasa; Kozai, Mina; Takei, Yuichiro; Masuda, Masashi; Kaneko, Ichiro; Taketani, Yutaka; Iwano, Masayuki; Miyamoto, Ken-ichi; Takeda, Eiji
• Author Heading: Nakahashi, Otoki; Yamamoto, Hironori; Tanaka, Sarasa; Kozai, Mina; Takei, Yuichiro; Masuda, Masashi; Kaneko, Ichiro; Taketani, Yutaka; Iwano, Masayuki; Miyamoto, Ken-ichi; Takeda, Eiji
• Publication, Distribution, etc.: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
• Publication Date: 2014-03-01
• Publication Date (W3CDTF): 2014-03-01
• Alternative Title: マウスにおいて短期間の食餌性リン制限は回腸fibroblast growth factor 15遺伝子発現量を増加させる
• Periodical title: Journal of Clinical Biochemistry and Nutrition
• No. or year of volume/issue: 54 2
• Volume: 54
• Issue: 2
• Pages: 102-108
• ISSN (Periodical Title): ISSN : 1880-5086; ISSN : 0912-0009
• Degree grantor/type: 徳島大学
• Date Granted: 2014-03-24
• Dissertation Number: 甲第2678号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: fibroblast growth factor 15; gene regulation analysis; inorganic phosphate; 1,25-dihydroxyvitamin D; mice
• Target Audience: 一般
• Note (General): Members of the fibroblast growth factor (FGF) 19 subfamily, including FGF23, FGF15/19, and FGF21, have a role as endocrine factors which influence the metabolism of inorganic phosphate (Pi) and vitamin D, bile acid, and energy. It has been reported that dietary Pi regulates circulating FGF23. In this study, the short-term effects of dietary Pi restriction on the expression of FGF19 subfamily members in mice were analyzed. An initial analysis confirmed plasma FGF23 levels positively correlated with the amount of dietary Pi. On the other hand, ileal Fgf15 gene expression, but not hepatic Fgf21 gene expression, was up-regulated by dietary Pi restriction. In addition, we observed the increase of plasma 1,25-dihydroxyvitamin D [1,25(OH)2D] levels by dietary Pi restriction, and the up-regulation of ileal Fgf15 mRNA expression by 1,25(OH)2D3 and vitamin D receptor (VDR). Importantly, dietary Pi restriction-induced Fgf15 gene expression was prevented in VDR-knockout mice. Furthermore, diurnal variations of plasma triglyceride concentrations and hepatic mRNA expression of the bile acid synthesis enzyme Cyp7a1 as one of Fgf15 negative target genes was influenced by dietary Pi restriction. These results suggest that dietary Pi restriction up-regulates ileal Fgf15 gene expression through 1,25(OH)2D3 and VDR, and may affect hepatic bile acid homeostasis.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2014 Society for Free Radical Research Japan
• Related Material (DOI): 10.3164/jcbn.13-109
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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