Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors

• 資料種別: 博士論文
• タイトル: Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors
• 著者・編者: Kondo, Takeshi; Endo, Itsuro; Aihara, Ken-ichi; Onishi, Yukiyo; Dong, Bingzi; Ohguro, Yukari; Kurahashi, Kiyoe; Yoshida, Sumiko; Fujinaka, Yuichi; Kuroda, Akio; Matsuhisa, Munehide; Fukumoto, Seiji; Matsumoto, Toshio; Abe, Masahiro
• 著者標目: Kondo, Takeshi; Endo, Itsuro; Aihara, Ken-ichi; Onishi, Yukiyo; Dong, Bingzi; Ohguro, Yukari; Kurahashi, Kiyoe; Yoshida, Sumiko; Fujinaka, Yuichi; Kuroda, Akio; Matsuhisa, Munehide; Fukumoto, Seiji; Matsumoto, Toshio; Abe, Masahiro
• 出版事項: 一般社団法人 日本内分泌学会
• 出版年月日等: 2016-04-25
• 出版年（W3CDTF）: 2016-04-25
• 並列タイトル等: 血清I型コラーゲンC末端テロペプチド濃度は心血管リスクを有する患者の頚動脈硬化と関連する; ICTP as a marker for atherosclerosis
• タイトル（掲載誌）: Endocrine Journal
• 巻号年月日等（掲載誌）: 63 4
• 掲載巻: 63
• 掲載号: 4
• 掲載ページ: 397-404
• ISSN（掲載誌）: ISSN : 1348-4540; ISSN : 0918-8959
• 授与機関名: 徳島大学
• 授与年月日: 2016-03-07
• 報告番号: 甲第2904号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: ICTP; Atherosclerosis; Max IMT; baPWV
• 対象利用者: 一般
• 一般注記: Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs ≥1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs <1.1 mm (3.33 ± 0.97 vs 2.82 ± 0.65 ng/mL, p<0.05). Serum ICTP concentration was also positively correlated with max IMT (p<0.001) or baPWV values (p<0.05). Multivariate analyses also revealed that serum ICTP concentrations were correlated with max IMT (p<0.001; 95% CI 0.200 to 0.454). These results suggest that serum ICTP concentrations can be used as a non-invasive biomarker for systemic atherosclerosis.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1507/endocrj.EJ15-0589
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/10/109666/20170929144106162616/LID201605311001.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/10/109666/20170929144106475673/LID201605311002.pdf fulltext