Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors

• Material Type: 博士論文
• Title: Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors
• Author/Editor: Kondo, Takeshi; Endo, Itsuro; Aihara, Ken-ichi; Onishi, Yukiyo; Dong, Bingzi; Ohguro, Yukari; Kurahashi, Kiyoe; Yoshida, Sumiko; Fujinaka, Yuichi; Kuroda, Akio; Matsuhisa, Munehide; Fukumoto, Seiji; Matsumoto, Toshio; Abe, Masahiro
• Author Heading: Kondo, Takeshi; Endo, Itsuro; Aihara, Ken-ichi; Onishi, Yukiyo; Dong, Bingzi; Ohguro, Yukari; Kurahashi, Kiyoe; Yoshida, Sumiko; Fujinaka, Yuichi; Kuroda, Akio; Matsuhisa, Munehide; Fukumoto, Seiji; Matsumoto, Toshio; Abe, Masahiro
• Publication, Distribution, etc.: 一般社団法人 日本内分泌学会
• Publication Date: 2016-04-25
• Publication Date (W3CDTF): 2016-04-25
• Alternative Title: 血清I型コラーゲンC末端テロペプチド濃度は心血管リスクを有する患者の頚動脈硬化と関連する; ICTP as a marker for atherosclerosis
• Periodical title: Endocrine Journal
• No. or year of volume/issue: 63 4
• Volume: 63
• Issue: 4
• Pages: 397-404
• ISSN (Periodical Title): ISSN : 1348-4540; ISSN : 0918-8959
• Degree grantor/type: 徳島大学
• Date Granted: 2016-03-07
• Dissertation Number: 甲第2904号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: ICTP; Atherosclerosis; Max IMT; baPWV
• Target Audience: 一般
• Note (General): Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs ≥1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs <1.1 mm (3.33 ± 0.97 vs 2.82 ± 0.65 ng/mL, p<0.05). Serum ICTP concentration was also positively correlated with max IMT (p<0.001) or baPWV values (p<0.05). Multivariate analyses also revealed that serum ICTP concentrations were correlated with max IMT (p<0.001; 95% CI 0.200 to 0.454). These results suggest that serum ICTP concentrations can be used as a non-invasive biomarker for systemic atherosclerosis.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1507/endocrj.EJ15-0589
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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