Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission

• 資料種別: 博士論文
• タイトル: Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission
• 著者・編者: Omoto, Katsuhiro; Maruhama, Kotaro; Terayama, Ryuji; Yamamoto, Yumiko; Matsushita, Osamu; Sugimoto, Tomosada; Oguma, Keiji; Matsuka, Yoshizo
• 著者標目: Omoto, Katsuhiro; Maruhama, Kotaro; Terayama, Ryuji; Yamamoto, Yumiko; Matsushita, Osamu; Sugimoto, Tomosada; Oguma, Keiji; Matsuka, Yoshizo
• 出版事項: MDPI
• 出版年月日等: 2015-08-04
• 出版年（W3CDTF）: 2015-08-04
• 並列タイトル等: 知覚神経節内の神経伝達物質による痛み情報伝達
• タイトル（掲載誌）: Toxins
• 巻号年月日等（掲載誌）: 7 8
• 掲載巻: 7
• 掲載号: 8
• 掲載ページ: 2906-2917
• ISSN（掲載誌）: ISSN : 2072-6651
• 授与機関名: 徳島大学
• 授与年月日: 2017-03-23
• 報告番号: 甲第3075号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Botulinum toxin; mechanical allodynia; dorsal root ganglion; transmitter release
• 対象利用者: 一般
• 一般注記: Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: Copyright: © 2015 Omoto et al ; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
• 関連情報（DOI）: 10.3390/toxins7082906
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/110096/20170929142133858173/LID201704251022.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/110096/20170929142134172855/LID201704251023.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/110096/20170929142134474077/LID201704251024.pdf fulltext