Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission

• Material Type: 博士論文
• Title: Cross-Excitation in Peripheral Sensory Ganglia Associated with Pain Transmission
• Author/Editor: Omoto, Katsuhiro; Maruhama, Kotaro; Terayama, Ryuji; Yamamoto, Yumiko; Matsushita, Osamu; Sugimoto, Tomosada; Oguma, Keiji; Matsuka, Yoshizo
• Author Heading: Omoto, Katsuhiro; Maruhama, Kotaro; Terayama, Ryuji; Yamamoto, Yumiko; Matsushita, Osamu; Sugimoto, Tomosada; Oguma, Keiji; Matsuka, Yoshizo
• Publication, Distribution, etc.: MDPI
• Publication Date: 2015-08-04
• Publication Date (W3CDTF): 2015-08-04
• Alternative Title: 知覚神経節内の神経伝達物質による痛み情報伝達
• Periodical title: Toxins
• No. or year of volume/issue: 7 8
• Volume: 7
• Issue: 8
• Pages: 2906-2917
• ISSN (Periodical Title): ISSN : 2072-6651
• Degree grantor/type: 徳島大学
• Date Granted: 2017-03-23
• Dissertation Number: 甲第3075号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Botulinum toxin; mechanical allodynia; dorsal root ganglion; transmitter release
• Target Audience: 一般
• Note (General): Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): Copyright: © 2015 Omoto et al ; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
• Related Material (DOI): 10.3390/toxins7082906
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/110096/20170929142133858173/LID201704251022.pdf fulltext

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