The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice

• 資料種別: 博士論文
• タイトル: The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice
• 著者・編者: Yoshikawa, Ryouhei; Yamamoto, Hironori; Nakahashi, Otoki; Kagawa, Tomohiro; Tajiri, Mari; Nakao, Mari; Fukuda, Shiori; Arai, Hidekazu; Masuda, Masashi; Iwano, Masayuki; Takeda, Eiji; Taketani, Yutaka
• 著者標目: Yoshikawa, Ryouhei; Yamamoto, Hironori; Nakahashi, Otoki; Kagawa, Tomohiro; Tajiri, Mari; Nakao, Mari; Fukuda, Shiori; Arai, Hidekazu; Masuda, Masashi; Iwano, Masayuki; Takeda, Eiji; Taketani, Yutaka
• 出版事項: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
• 出版年月日等: 2018-01-01
• 出版年（W3CDTF）: 2018-01-01
• 並列タイトル等: 年齢に応じた血中活性型ビタミンD濃度, 腎Cyp27b1およびCyp24a1発現に対する食餌性リン反応性の変化には腎α-Klotho遺伝子発現が関連する
• タイトル（掲載誌）: Journal of Clinical Biochemistry and Nutrition
• 巻号年月日等（掲載誌）: 62 1
• 掲載巻: 62
• 掲載号: 1
• 掲載ページ: 68-74
• ISSN（掲載誌）: ISSN : 1880-5086; ISSN : 0912-0009
• 授与機関名: 徳島大学
• 授与年月日: 2017-10-26
• 報告番号: 甲第3119号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: α-Klotho; age-related change; vitamin D metabolism; inorganic phosphate; mice
• 対象利用者: 一般
• 一般注記: In this study, we investigated the relationship between age-related changes in renal α-Klotho gene expression, vitamin D metabolism and the responsiveness of dietary phosphate in 1, 2 and 13 month-old mice fed a high phosphate (phosphate 1.2%) diet or low phosphate (phosphate 0.02%) diet for 5 days. We found that 1,25-dihydroxyvitamin D levels in plasma were significantly lower in the high phosphate group than the low phosphate group for 1 and 2 month-old mice, but not 13 month-old mice. In addition, in the high phosphate group plasma 1,25-dihydroxyvitamin D levels were decreased in 2 month-old mice relative to 1 month-old mice, but 13 month-old mice had higher levels than 2 month-old mice. In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Interestingly, renal α-Klotho mRNA and protein levels were significant change with age. Furthermore, α-Klotho mRNA expression showed a significant negative correlation with plasma 1,25-dihydroxyvitamin D levels in the high phosphate group. Our results suggest that age-related alterations in renal α-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2018 Society for Free Radical Research Japan
• 関連情報（DOI）: 10.3164/jcbn.17-20
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

https://repo.lib.tokushima-u.ac.jp/files/public/11/111009/20180124164801500228/k3119_abstract_review.pdf fulltext

https://repo.lib.tokushima-u.ac.jp/files/public/11/111009/20180208181229488397/k3119_fulltext.pdf fulltext