The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice

• Material Type: 博士論文
• Title: The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice
• Author/Editor: Yoshikawa, Ryouhei; Yamamoto, Hironori; Nakahashi, Otoki; Kagawa, Tomohiro; Tajiri, Mari; Nakao, Mari; Fukuda, Shiori; Arai, Hidekazu; Masuda, Masashi; Iwano, Masayuki; Takeda, Eiji; Taketani, Yutaka
• Author Heading: Yoshikawa, Ryouhei; Yamamoto, Hironori; Nakahashi, Otoki; Kagawa, Tomohiro; Tajiri, Mari; Nakao, Mari; Fukuda, Shiori; Arai, Hidekazu; Masuda, Masashi; Iwano, Masayuki; Takeda, Eiji; Taketani, Yutaka
• Publication, Distribution, etc.: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
• Publication Date: 2018-01-01
• Publication Date (W3CDTF): 2018-01-01
• Alternative Title: 年齢に応じた血中活性型ビタミンD濃度, 腎Cyp27b1およびCyp24a1発現に対する食餌性リン反応性の変化には腎α-Klotho遺伝子発現が関連する
• Periodical title: Journal of Clinical Biochemistry and Nutrition
• No. or year of volume/issue: 62 1
• Volume: 62
• Issue: 1
• Pages: 68-74
• ISSN (Periodical Title): ISSN : 1880-5086; ISSN : 0912-0009
• Degree grantor/type: 徳島大学
• Date Granted: 2017-10-26
• Dissertation Number: 甲第3119号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: α-Klotho; age-related change; vitamin D metabolism; inorganic phosphate; mice
• Target Audience: 一般
• Note (General): In this study, we investigated the relationship between age-related changes in renal α-Klotho gene expression, vitamin D metabolism and the responsiveness of dietary phosphate in 1, 2 and 13 month-old mice fed a high phosphate (phosphate 1.2%) diet or low phosphate (phosphate 0.02%) diet for 5 days. We found that 1,25-dihydroxyvitamin D levels in plasma were significantly lower in the high phosphate group than the low phosphate group for 1 and 2 month-old mice, but not 13 month-old mice. In addition, in the high phosphate group plasma 1,25-dihydroxyvitamin D levels were decreased in 2 month-old mice relative to 1 month-old mice, but 13 month-old mice had higher levels than 2 month-old mice. In fact, plasma 1,25-dihydroxyvitamin D levels showed a significant correlation with vitamin D metabolism gene Cyp27b1 and Cyp24a1 mRNA expression in the high phosphate group. Interestingly, renal α-Klotho mRNA and protein levels were significant change with age. Furthermore, α-Klotho mRNA expression showed a significant negative correlation with plasma 1,25-dihydroxyvitamin D levels in the high phosphate group. Our results suggest that age-related alterations in renal α-Klotho expression could affect the responsiveness of dietary phosphate to vitamin D metabolism.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2018 Society for Free Radical Research Japan
• Related Material (DOI): 10.3164/jcbn.17-20
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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