Excessive dietary phosphorus intake impairs endothelial function in young healthy men : a time- and dose-dependent study

• 資料種別: 博士論文
• タイトル: Excessive dietary phosphorus intake impairs endothelial function in young healthy men : a time- and dose-dependent study
• 著者・編者: Nishi, Tamae; Shuto, Emi; Ogawa, Mariko; Ohya, Miho; Nakanishi, Misaki; Masuda, Masashi; Katsumoto, Misaki; Yamanaka-Okumura, Hisami; Sakai, Tohru; Takeda, Eiji; Sakaue, Hiroshi; Taketani, Yutaka
• 著者標目: Nishi, Tamae; Shuto, Emi; Ogawa, Mariko; Ohya, Miho; Nakanishi, Misaki; Masuda, Masashi; Katsumoto, Misaki; Yamanaka-Okumura, Hisami; Sakai, Tohru; Takeda, Eiji; Sakaue, Hiroshi; Taketani, Yutaka
• 出版事項: Faculty of Medicine Tokushima University
• 出版年月日等: 2015-08
• 出版年（W3CDTF）: 2015-08
• 並列タイトル等: 過剰なリン摂取は若年健常男性において血管内皮機能を障害する : 時間・用量試験
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 62 3-4
• 掲載巻: 62
• 掲載号: 3-4
• 掲載ページ: 167-172
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2015-03-23
• 報告番号: 甲第2847号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: phosphorus; endothelial dysfunction; flow-mediated vasodilation; hyperphosphatemia; chronic kidney disease
• 対象利用者: 一般
• 一般注記: Excessive dietary phosphorus (P) has been speculated to be a risk factor for cardiovascular disease (CVD). Here, we performed a double-blinded crossover study to investigate the time- and dose-dependent effects of dietary P intake on endothelial function in healthy subjects. Sixteen healthy male volunteers were given meals containing 400, 800, and 1,200 mg P (P400, P800, and P1200 meals, respectively) with at least 7 days between doses. There were no differences in nutritional composition among the experimental diets except for P content. Blood biochemistry data and flow-mediated dilation (%FMD) of the brachial artery were measured while fasted, at 0 h, 1 h, 2 h, and 4 h after meal ingestion, and the next morning while fasted. The P800 and P1200 meals significantly increased serum P levels at 1-4 h after ingestion. A significant decrease in %FMD was observed between 1-4 h, while the P400 meal did not affect %FMD. We observed no differences among meals in serum P levels or %FMD the next morning. A significant negative correlation was observed between %FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.62.167
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/111273/20190802134849351807/LID201506051001.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/111273/20190802134849707902/LID201509141001.pdf fulltext