Excessive dietary phosphorus intake impairs endothelial function in young healthy men : a time- and dose-dependent study

• Material Type: 博士論文
• Title: Excessive dietary phosphorus intake impairs endothelial function in young healthy men : a time- and dose-dependent study
• Author/Editor: Nishi, Tamae; Shuto, Emi; Ogawa, Mariko; Ohya, Miho; Nakanishi, Misaki; Masuda, Masashi; Katsumoto, Misaki; Yamanaka-Okumura, Hisami; Sakai, Tohru; Takeda, Eiji; Sakaue, Hiroshi; Taketani, Yutaka
• Author Heading: Nishi, Tamae; Shuto, Emi; Ogawa, Mariko; Ohya, Miho; Nakanishi, Misaki; Masuda, Masashi; Katsumoto, Misaki; Yamanaka-Okumura, Hisami; Sakai, Tohru; Takeda, Eiji; Sakaue, Hiroshi; Taketani, Yutaka
• Publication, Distribution, etc.: Faculty of Medicine Tokushima University
• Publication Date: 2015-08
• Publication Date (W3CDTF): 2015-08
• Alternative Title: 過剰なリン摂取は若年健常男性において血管内皮機能を障害する : 時間・用量試験
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 62 3-4
• Volume: 62
• Issue: 3-4
• Pages: 167-172
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2015-03-23
• Dissertation Number: 甲第2847号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: phosphorus; endothelial dysfunction; flow-mediated vasodilation; hyperphosphatemia; chronic kidney disease
• Target Audience: 一般
• Note (General): Excessive dietary phosphorus (P) has been speculated to be a risk factor for cardiovascular disease (CVD). Here, we performed a double-blinded crossover study to investigate the time- and dose-dependent effects of dietary P intake on endothelial function in healthy subjects. Sixteen healthy male volunteers were given meals containing 400, 800, and 1,200 mg P (P400, P800, and P1200 meals, respectively) with at least 7 days between doses. There were no differences in nutritional composition among the experimental diets except for P content. Blood biochemistry data and flow-mediated dilation (%FMD) of the brachial artery were measured while fasted, at 0 h, 1 h, 2 h, and 4 h after meal ingestion, and the next morning while fasted. The P800 and P1200 meals significantly increased serum P levels at 1-4 h after ingestion. A significant decrease in %FMD was observed between 1-4 h, while the P400 meal did not affect %FMD. We observed no differences among meals in serum P levels or %FMD the next morning. A significant negative correlation was observed between %FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.62.167
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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