Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus

• 資料種別: 博士論文
• タイトル: Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus
• 著者・編者: Takahashi, Etsuhisa; Indalao, Irene L.; Sawabuchi, Takako; Mizuno, Keiko; Sakai, Satoko; Kimoto, Takashi; Kim, Hyejin; Kido, Hiroshi
• 著者標目: Takahashi, Etsuhisa; Indalao, Irene L.; Sawabuchi, Takako; Mizuno, Keiko; Sakai, Satoko; Kimoto, Takashi; Kim, Hyejin; Kido, Hiroshi
• 出版事項: Elsevier
• 出版年月日等: 2017-11-23
• 出版年（W3CDTF）: 2017-11-23
• 並列タイトル等: クラリスロマイシンはインフルエンザAウイルスに感染したマウスにおいて、monocyte chemoattractant protein-1とmatrix metalloproteinase-9の発現誘導を抑制し、肺と心臓における病理学的変化を改善する
• タイトル（掲載誌）: Comparative Immunology, Microbiology and Infectious Diseases
• 巻号年月日等（掲載誌）: 56
• 掲載巻: 56
• 掲載ページ: 6-13
• ISSN（掲載誌）: ISSN : 0147-9571
• 授与機関名: 徳島大学
• 授与年月日: 2018-01-25
• 報告番号: 甲第3122号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Matrix metalloproteinase-9; Macrolide; Clarithromycin; Influenza A virus; Multiple organ failure; Evans’ blue extravasation; Influenza A virus infection
• 対象利用者: 一般
• 一般注記: The influenza A virus (IAV)–cytokine–trypsin/matrix metalloproteinase-9 (MMP-9) cycle is one of the important mechanisms of multiple organ failure in severe influenza. Clarithromycin, a macrolide antibiotic, has immune modulatory and anti-inflammatory effects. We analyzed the effects of clarithromycin on the induction of chemokines, cytokines, MMP-9, trypsin, vascular hyper-permeability and inflammatory aggravation in mice with IAV infection. IAV/Puerto Rico/8/34(H1N1) infection increased the levels of monocyte chemoattractant protein- 1 (MCP-1) and cytokines in serum, and MMP-9 and trypsin in serum and/or the lungs and heart. Clarithromycin significantly suppressed the induction of serum MCP-1 and MMP-9 and vascular hyperpermeability in these organs in the early phase of infection, but did not suppress the induction of trypsin, IL-6 or IFN-γ. Histopathological examination showed that clarithromycin tended to reduce inflammatory cell accumulation in the lungs and heart. These results suggest that clarithromycin suppresses infection-related inflammation and reduces vascular hyperpermeability by suppressing the induction of MCP-1 and MMP-9.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• 関連情報（DOI）: 10.1016/j.cimid.2017.11.002
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/111401/20180412133105941674/k3122_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/111401/20180412133106259565/k3122_fulltext.pdf fulltext