Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus

• Material Type: 博士論文
• Title: Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus
• Author/Editor: Takahashi, Etsuhisa; Indalao, Irene L.; Sawabuchi, Takako; Mizuno, Keiko; Sakai, Satoko; Kimoto, Takashi; Kim, Hyejin; Kido, Hiroshi
• Author Heading: Takahashi, Etsuhisa; Indalao, Irene L.; Sawabuchi, Takako; Mizuno, Keiko; Sakai, Satoko; Kimoto, Takashi; Kim, Hyejin; Kido, Hiroshi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2017-11-23
• Publication Date (W3CDTF): 2017-11-23
• Alternative Title: クラリスロマイシンはインフルエンザAウイルスに感染したマウスにおいて、monocyte chemoattractant protein-1とmatrix metalloproteinase-9の発現誘導を抑制し、肺と心臓における病理学的変化を改善する
• Periodical title: Comparative Immunology, Microbiology and Infectious Diseases
• No. or year of volume/issue: 56
• Volume: 56
• Pages: 6-13
• ISSN (Periodical Title): ISSN : 0147-9571
• Degree grantor/type: 徳島大学
• Date Granted: 2018-01-25
• Dissertation Number: 甲第3122号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Matrix metalloproteinase-9; Macrolide; Clarithromycin; Influenza A virus; Multiple organ failure; Evans’ blue extravasation; Influenza A virus infection
• Target Audience: 一般
• Note (General): The influenza A virus (IAV)–cytokine–trypsin/matrix metalloproteinase-9 (MMP-9) cycle is one of the important mechanisms of multiple organ failure in severe influenza. Clarithromycin, a macrolide antibiotic, has immune modulatory and anti-inflammatory effects. We analyzed the effects of clarithromycin on the induction of chemokines, cytokines, MMP-9, trypsin, vascular hyper-permeability and inflammatory aggravation in mice with IAV infection. IAV/Puerto Rico/8/34(H1N1) infection increased the levels of monocyte chemoattractant protein- 1 (MCP-1) and cytokines in serum, and MMP-9 and trypsin in serum and/or the lungs and heart. Clarithromycin significantly suppressed the induction of serum MCP-1 and MMP-9 and vascular hyperpermeability in these organs in the early phase of infection, but did not suppress the induction of trypsin, IL-6 or IFN-γ. Histopathological examination showed that clarithromycin tended to reduce inflammatory cell accumulation in the lungs and heart. These results suggest that clarithromycin suppresses infection-related inflammation and reduces vascular hyperpermeability by suppressing the induction of MCP-1 and MMP-9.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• Related Material (DOI): 10.1016/j.cimid.2017.11.002
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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