Effect of olive oil consumption on aging in a senescence-accelerated mouse-prone 8 (SAMP8) model

• 資料種別: 博士論文
• タイトル: Effect of olive oil consumption on aging in a senescence-accelerated mouse-prone 8 (SAMP8) model
• 著者・編者: Bando, Masahiro; Masumoto, Saeko; Kuroda, Masashi; Tsutsumi, Rie; Sakaue, Hiroshi
• 著者標目: Bando, Masahiro; Masumoto, Saeko; Kuroda, Masashi; Tsutsumi, Rie; Sakaue, Hiroshi
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2019-08
• 出版年（W3CDTF）: 2019-08
• 並列タイトル等: Senescence-accelerated mouse-prone 8 (SAMP8)マウスにおけるオリーブオイル摂取の老化への効果; Effects of olive oil in SAMP8 mice
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 66 3-4
• 掲載巻: 66
• 掲載号: 3-4
• 掲載ページ: 241-247
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2019-03-22
• 報告番号: 甲第3276号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: Mediterranean diet; olive oil; MUFA; SAMP8; aging; passive avoidance
• 対象利用者: 一般
• 一般注記: Background : Mediterranean diets have been linked to a reduced risk of cancer, vascular illnesses, Parkinson’s and Alzheimer’s disease. Olive oil is the primary fat source in the Mediterranean diet ; however, only a few studies have investigated the effect of olive oil on aging. In the present study, we aimed to determine whether consumption of olive oil significantly influences aging and memory in senescence-accelerated mouse-prone 8 (SAMP8). Methods : SAMP8 and senescence-accelerated mouse resistant 1 (SAMR1) mice were fed either 7% soy oil or 1% olive oil and 6% soy oil during a six-month study period. Reduction in memory in passive avoidance learning was examined after two months from the initiation of the experiment. Results : The weight of organs including the liver, kidney, spleen, and fat tissue changed significantly and memory performance was reduced in SAMP8 than in SAMR1 mice. There were no significant differences in SAMP8 and SAMR1 mice; however, blood triglyceride level decreased significantly in SAMP8 mice fed on olive oil. Conclusions : These results suggest that consuming olive oil may not have a protective role in aging and memory recall, but beneficial effects may be related to improvement in lipid metabolism.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.66.241
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/113365/20190607135550736996/k3276_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113365/20191219142144685697/k3276_fulltext.pdf fulltext